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samenvatting Ethanolmetabolisme (medische biochemie)

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Over het ethanol/alcoholmetabolisme met focus op de effecten van chronisch alcoholisme op ons metabolisme.

Institution
Universiteit Antwerpen (UA)
Course
Celbiologie partim medische biochemie

Content preview

Ethanolmetabolisme


= alcoholmetabolisme

- Bij opname ethanol: vorming
acetyl -coA in 3 stappen thv
lever
o maar enorm veel
productie NADH
- Grootste probleem
metaboliseren ethanol:
overproductie NADH
- Zowel in cytoplasma als
mitochondrien overmatige
productie NADH
- Acetyl-coA gaat nr allemaal nr
krebcylcus, maar werkt nt goed
dr teveel NAD/NADH => acetyl-
coA gaat nr ketogenese
- Eindproduct  toxisch!




Chronische alcoholieker
Bij chronisch alc gebruik: gaat metabolisme in de war sturen
=> alle reacties met NAD / NADH w beïnvloed
=> cofactoren beginnen elkaar tegen te werken

1. glycolyse & lactaat acidose
In glycolyse: aantal reacties waar NADH belangrijk is:
Stel frequent alcohol drinken => cytoplasma overladen
met ongeregeld NADH (volledig uit exogene bron) =>
gaat alle reacties tegenwerken:
Glycolyse gaat glycodeficcient gaan => slechtere ATP




productie

=> intermediaire shuttle nr lipidesynthese => chronische alc veel vet aanmaaken
+ ook in verzuurde toestand: overmaat NADH shuttelen nr lactaat = lactaatacidose
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Institution
Universiteit Antwerpen (UA)
Study
Geneeskunde
Course
Celbiologie partim medische biochemie

Document information

Uploaded on
November 8, 2023
Number of pages
2
Written in
2022/2023
Type
SUMMARY

Subjects

  • geneeskunde
  • bachelor 1
  • medische biochemie
  • ethanol
  • ethanolmetabolisme
  • glycolyse
  • lactaat
  • gluconeogenese
  • lipogenese
  • chronische alcoholieker
  • alcoholmetabolisme
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