OBGYN PAEA Questions with Complete Solutions Rated A+

1. What gene is associated with Ovarian Neoplasms? - P53 gene - CA 125 tumor marker 2. What is the first presenting symptom of cervical carcinoma? - Post coital bleeding/spotting 3. What is the proper clinical intervention for cervical carcinoma? - Diagnosis: colposcopy w/ bx. - Screening: Pap smear w/ cytology - CIN I--> repeat cytology q6mo x 2 or repeat HPV testing in 1 year - CIN II/III--> treat with surgical excision (LEEP > cold knife cone) - If preinvasive / microinvasive (stage I-Ia) → simple hysterectomy, consider cold knife cone if fertility highly desired - If early (stage Ia-2 to IIa) → radiation or radical hysterectomy + bilat LN dxn •Includes parametria, upper vaginal cuff, uterosacral / cardinal ligaments, vascular supply •Decision based on age, ability to tolerate surgery, ? nearby rad facilities •If young, may lean towards surgery (keep ovaries!) - If advanced (IIb-IV), treat with chemoradiation (cisplatin-based + internal & external rad) - If recurrent, can treat with pelvic exenteration & get 50% survival