USMLE STEP 1 Pharmacology (Chamberlain)

What are the major functions of the α1 receptor? Correct Answer: Increase vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter muscle contraction What are the major functions of the α2 receptor? Correct Answer: Decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production What are the major functions of the β1 receptor? Correct Answer: Increase heart rate, increase contractility, increase renin release, increase lipolysis What are the major functions of the β2 receptor? Correct Answer: Vasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous humor production What are the major functions of the M1 receptor? Correct Answer: CNS, enteric nervous system What are the major functions of the M2 receptor? Correct Answer: Decrease heart rate and contractility of atria What are the major functions of the M3 receptor? Correct Answer: Increase exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation) What are the major functions of the D1 receptor? Correct Answer: Relaxes renal vascular smooth muscle What are the major functions of the D2 receptor? Correct Answer: Modulates transmitter release, especially in the brain What are the major functions of the H1 receptor? Correct Answer: Increase nasal and bronchial mucus production, increase vascular permeability, contraction of bronchioles, pruritis, pain What are the major functions of the H2 receptor? Correct Answer: Increase gastric acid secretion What are the major functions of the V1 receptor? Correct Answer: Increase vascular smooth muscle contraction What are the major functions of the V2 receptor? Correct Answer: Increase H2O permeability and reabsorption in collecting tubules of kidney (V2 is found in the "2" kidneys) What receptors are associate with Gq? Correct Answer: H1, α1, V1, M1, and M3