8 Hr Waiver Training complete Study Guide with correct solutions | Latest 2023/2024

8 Hr Waiver Training complete Study Guide with correct solutions | Latest 2023/2024 opioid mu receptor agonist drug effects: acute ☑️ euphoria, N&V, depressed respiration, sedation, analgesia, pruritus, miosis opioid mu receptor agonist drug effects: large dose acute ☑️ nonresponsive, pinpoint pupils, anoxia/dilated pupils, bradycardia & hypotension, cyanotic, flacidity, pulm edema, slow or absent respiration opioid mu receptor agonist drug effects: chronic ☑️ dependence, withdrawal, tolerance, lethargy, constipation how does opioids cause constipation ☑️ mu receptors in bowels, binding to mu receptors cause slowing of peristalsis how does opioid cause respiratory depression ☑️ depression of medullary respiratory center, decreased tidal volume and minute ventilation, dec respiratory response to elevated CO2, hypercapnea,/hypoxia/dec O2 sat (sedation occurs before significant respiratory depression so it's a warning sign to look out for) opioid characteristics that increase euphoria ☑️ 1. route of administration (smoking --> IV --> SQ --> oral/intranasal) 2. half-life (fentanyl --> heroin --> methadone) 3. lipophilicity faster, shorter half-life, higher lipophilicity has higher risk of misuse heroine, methadone, oxycodone are (partial/full) agonist ☑️ full buprenorphine is a (partial/full) agonist ☑️ full naloxone, naltrexone are opioid (agonist/antagonist) ☑️ antagonist (full)