Porth's Pathophysiology 10th Edition Ch 24- Disorders of White Blood Cells and Lymphoid Tissues

24 Disorders of White Blood Cells and Lymphoid Tissues Question 1 1 out of 1 points A child has Down syndrome and has been experiencing unexplained nose bleeds for the past several mon ths. His blood tests identify blast cells in the peripheral smear. In addition to nose bleeds, his acute leukemia will typically manifest which of the following signs/symptoms? Select all that apply. Selected Answers: A. Fatigue due to RBC de!ciency C. Infections due to neutropenia E. Bleeding due to thrombocytopenia Correct Answers: A. Fatigue due to RBC deficiency C. Infections due to neutropenia E. Bleeding due to thrombocytopen ia Response Hypogammaglobulinemia is common with chron ic lymphocytic Feedback: leukemia, in addition to all of the manifestations of a blood cell malignancy. Infections, fatigue, and bleeding are seen in all clients with acute leukemias and will also be present in clients with chronic leukemias. The accelerated phase of CML is characterized by enlargement of the spleen and progressive symptoms. Splenomegaly often causes a feeling of abdominal fullness and discomfort. Solid tumors on the kidneys are not associated with CLL. Question 2 1 out of 1 points A client is undergoing a diagnostic workup to rule out multiple myeloma. Which of the following diagnostic !ndings would con!rm the diagnosis of multiple myeloma? Selected D. Answer: Plasma cells greater than 10% on bone marrow biopsy Correct Answer: D. Plasma cells greater than 10% on bone marrow biopsy Response Multiple myeloma is a plasma cell malignancy that results in Feedback: proliferation of a single monoclonal immunoglobulin. Multiple myeloma cells are found in the marrow and as osteolytic lesions in all bones. B-cell lymphocytes normally stimulate plasma cells to produ ce immunoglobulin when needed; T cells are not involved in the process. Question 3 1 out of 1 points The 16-year-old boy has enlarged lymph nodes and a sore throat. His girlfriend was recently diagnosed with infectious mononucleosis. While educating this teenager, the nurse emphasizes that infectious mononucleosis is caused by which pathogen and usually transmitted via: Selected Answer: A. Epstein-Barr virus; saliva Correct Answer: A. Epstein-Barr virus; saliva Response Infectious mononucleosis is caused by Epstein-Barr virus and is Feedback: commonly transmitted throug h saliva. Once the B cells are infected, mononucleosis is diagnosed by the presence of heterophil antibodies in the blood. Infectious mononucleosis is a B-cell viral infection. Cytotoxic T cells attack the virus and limit the number of infected B cells without eliminating them.