NURS 3305 & 5005 Infectious Disease Drug Tables.

L CELL WALL IN HIBIT O RS PENICILLINS (and related drug)- Inhibiting cell wall penicillin G narrow-spectrum penicillinase sensitive penicillin Streptococcus; many G+ & some G- ; Syphilis MOA: Weaken Cell wall, causing bacteria to take up excessive water and rupture. Bactericidal, only killing dividing bacteria. Bind to penicillin binding proteins to weaken cell wall. GI heart burn, diarrhea, stomatitis, discolored tongue, Multiple DDI’s Increased bleeding time of anticoagulants; inactivates aminoglycosides in in same IV bag; potentially decreased efficient of oral contraceptive. Penicillin G will not be affective towards a bacteria creating penicillinase Streptococcus sp. (Active against most Gram positive tentanus, gangrene and anthrax, syphilis Mechanism of Bacterial Resistance • Inability of penicillins to reach their target • Inactivation of penicillins by bacterial enzymes (penicillinase (nafcillin) (Nallpen) narrow-spectrum penicillinase resistant penicillin MSSA; staphylococcus MOA: Weaken Cell wall, causing bacteria to take up excessive water and rupture. Bactericidal, only killing dividing bacteria