UNE BioChem 1005 - Unit 2 review| Exam Questions With Correct Answers

UNE BioChem 1005 - Unit 2 review| Exam Questions With Correct Answers 1. Pyruvate dehydrogenase kinase catalyzes a reaction that results in which of the following? - CORRECT ANSWER-The phosphorylation and inactivation of E1 subunit (pyruvate dehydrogenase complex 1. Which of the following intermediates is an allosteric activator of pyruvate kinase? - CORRECT ANSWER-a. Fructose 1.6 bisphosphate 1. Which of the following is the initial second messenger in the signaling cascade initiated by glucagon? - CORRECT ANSWER-a. cAMP 1. Hereditary fructose intolerance in caused by a deficiency in aldolase B. These individuals may present with hypoglycemia due to an accumulation of fructose 1-P in the cell and inhibition of which of the following pathways? - CORRECT ANSWER-a. Gluconeogenesis and glycogenolysis 1. Following insulin binding its receptor and autophosphorylation of the beta chain, what is the initial step in the cascade of events? - CORRECT ANSWER-a. Recruitment of the insulin receptor substrate 1. What sequence of enzymes allows for the synthesis of glycogen from glucose 6-P? - CORRECT ANSWER-Phosphoglucomutase, UDP-glucose phosphorylase, glycogen synthase amylo-(1,4a1,6)-transglycosylase 1. Complex II, succinate dehydrogenase, is not considered to be part of the process of oxidative phosphorylation because it is unable to do which of the following activities? - CORRECT ANSWER-a. Pump protons from the mitochondrial matrix to the intermembrane space 1. Which of the following is the primary GLUT transporter in skeletal muscle and adipose tissue? - CORRECT ANSWER-GLUT 4 1. Which of the following best describes the net effect of the 8 steps of the TCA cycle? - CORRECT ANSWER-a. This process completely oxidizes an acetyl group to carbon dioxide 1. Which of the following enzymes is correctly paired with this activator? - CORRECT ANSWER-a. Pyruvate dehydrogenase complex, pyruvate 1. ATP is a high energy molecule that is often hydrolyzed during reactions. The energy within ATP is stored primarily in which of the following compounds of the molecule? - CORRECT ANSWER-a. In the high energy phosphate bonds 1. Which of the following is a key inhibitor of the a-ketoglutarate dehydrogenase? - CORRECT ANSWER-NADH 1. As electrons flow through complexes in the inner mitochondrial membrane, protons are pumped from the matrix to the intermembrane space. Which of the following statements is most reflective of the pH in the intermembrane space? - CORRECT ANSWER-a. The pH is higher in the matrix when compared to the intermembrane space 1. Pyruvate dehydrogenase complex is highly regulated. The enzyme will be most active when which of the following compounds is high? - CORRECT ANSWER-Pyruvate 1. TCA cycle intermediates are always being removed for various metabolic processes. One example of this is the removal of succinyl CoA which is used for the synthesis of which of the following compounds? - CORRECT ANSWER-Heme 1. The fully reduced quinol form of CoQ contains which of the following combinations of electrons and protons? - CORRECT ANSWER-2 e- and two protons 1. Individuals with a deficiency in glucose 6-P dehydrogenase often present with hemolytic anemia. This is primarily due to a deficiency in which of the following metabolic products? - CORRECT ANSWER-NADPH 1. Within the red blood cell, glucose can be oxidized to which of the following products? - CORRECT ANSWER-lactate and ribose