AAMC FL 1 FULL REVIEW- Biochem with Questions and Answers

Based on the data presented in the passage, which statement best describes the HSP110ΔE9 allele? A.Cancer-promoting and dominant to HSP110WT B.Cancer-promoting and recessive to HSP110WT C.Cancer-suppressing and dominant to HSP110WT D.Cancer-suppressing and recessive to HSP110WT - Cross out A and B. LOOK AT THE FIGURE! Tumor volume is DOWN. Table 2 shows that HSP110ΔE9 allele when mixed with HSP110WT there is more apoptotic cells. So it's dominant. SLOW THE HECK DOWN AND READ Based on the passage, in MSI CRC primary tumor cells, the size of the deletion in the HSP110 T17 microsatellite is inversely correlated with: A.the amount of HSP110ΔE9 protein expressed. B.the number of mature HSP110WT transcripts synthesized. C.the frequency of the omission of HSP110 Exon 9 during splicing. D.the extent of premature translation termination in Exon 10. - INVERSELY CORRELATED WITH According to Table 1, as the size of the deletion increases, the amount of HSP110ΔE9 and HSP110WT transcripts synthesized increase and decrease, respectively. also: The larger HSP110 T17 deletions cause Exon 9 to be omitted from the final sequence during pre-mRNA processing. This generates a premature stop codon in Exon 10, resulting in the mutant protein HSP110ΔE9. You're going to have MORE PRE-MATURE transcripts, SO LESS mature ones. A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a woman that does not carry this mutation in any of her tissues have a child. What is the percent chance that the child will inherit the CRC mutation? A.0% B.25% C.50% D.100% passage: People with MSI CRC have HSP110ΔE9 transcripts in cancerous tissue only. - YOU AINT GONNA PASS DOWN CANCEROUS TISSUE A! Which nucleotide pairing(s) would be recognized by the MMR system during DNA replication? dTMP and dCMP dGMP and dAMP dAMP and dTMP A.I only B.III only C.I and II only D.I, II, and III - Looking for mismatched bases! Roman numeral 2 comes up twice so start there. G and A are not paired correctly (cross out a and b) Now looking at 3. Adenine and Thymine are paired together normally, eliminate D, end with C. The information in the passage best supports the conclusion that Intron 8 of HSP110 most likely contains which of the following? A.Stop codon B.Splice acceptor site C.HSP110 gene promoter D.Partial coding sequence of HSP110 - Introns are useless pieces of shit only think it will have is a place for the splice some to come and crunch it. According to the information in the passage, HSP110 is most likely which type of protein? A.Adhesion B.Chaperone C.Clathrin D.Enzyme Passage: HSP110 can bind structurally similar heat shock proteins and functions to facilitate proper protein folding and to reduce levels of nonfunctional protein aggregates. - FACILITATING PROTEIN FOLDING = CHAPERONE Which amino acid, in addition to tryptophan, is most likely to be transported by AT1? A.Phenylalanine B.Lysine C.Arginine D.Glutamate - A. only one that is neutral and aromatic! Based on the information in the passage, a mature AT1 mRNA is most likely to contain a sequence coding for which genetic factor(s)? A.Signal sequence B.Introns C.Promoter D.Nuclear localization signal Passage: AT1 localization to the luminal plasma membrane of small intestinal epithelial cells. AT1 simultaneously transports tryptophan against its concentration gradient and a sodium ion along its concentration gradient into the cytoplasm of intestinal epithelial cells. - Aight. So we know this sucker is a transmembrane protein transporter. They transport ish by a signal sequence (A).