GENERAL PHARMACOLOGY

1. During the treatment of chronic heart failure with digoxin in a patient having bradycardia, nausea, vomiting, blurred vision. Which drug is the antidote in this case? A. Atropine sulphate B. Tetacinum calcium C. Dipiroximum D. Amyl nitrite E. Unithiol 2. During digitoxin therapy for chronic cardiac insufficiency, a patient developed signs of intoxication with this preparation. The patient was prescribed unithiol. What is the mechanism of unithiol action in case of intoxication with cardiac glycosides? A Reduction of К+-Na+-adenosine triphosphatase B Binding of calcium ions C Increase of sodium concentration in the cardiomyocytes D Increased potassium permeability in the cardiomyocytes E Binding of glycoside into the complex compound 3. Treatment of poisonings with inorganic compounds includes the use of the following antidote: A. Unithiol B. Dexamethasone C. Desferal D. Tetacinum-calcium E. Naloxone 4. A patient with signs of mercury poisoning has been delivered into an admission room. What antidote should be prescribed in this case? A. Naloxone B. Calcium chloride C. Atropine sulfate D. Unithiol E. Proserin 5. A patient with signs of cardiac glycosides intoxication was prescribed Unithiol. What is the mechanism of drug action in this case? A. Reactivation of membrane K+, Na+ - adenosine triphosphatase B. Induction of cardiac glycoside metabolism C. Increased Na+ content in myocardium D. Binding of ionized Ca2+ E. Increased permeability of K+ into myocardiocytes