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Summary WJEC (England) Eduqas A-Level Biology 2. Continuity of Life - 3. Human Reproduction

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I achieved a high A* Grade in my final A-Level exams using these notes!!! I believe you can achieve an A* if you can memorise these notes! Simply use blurting, a method of active recall, to write everything you remember from the notes, then identify the parts you couldn’t remember, then repeat until you can remember it all! If you can do that, you’ve got an A* in the bag! They are clear, concise, and are laid out according to the specification; there is no information missing or in excess. Good Luck!!!

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May 2, 2023
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a. male reproductive system
testes – contained in scrotum
- seminiferous tubules
o Interstitial Leydig cells: secrete testosterone – stimulate spermatogenesis
o Sertoli cells – fluid: nourish spermatids & protect from immune system
epididymis: sperm maturation & storage – become motile
vas deferens – carries sperm from epididymis to penis through urethra
accessory glands = semen
 seminal vesicle: secretes mucus (into vas deferens) – fructose for respiration for energy
 prostate gland (contains ejaculatory duct): secretes zinc-containing prostate fluid
- maintain sperm motility
- nutrients
- alkaline: neutralise acidity of urine & vaginal tract

b. spermatogenesis = spermatozoa – seminiferous tubules (from lining to lumen)
germinal epithelium mitosis = spermatogonia mitosis = primary spermatocytes
primary spermatocytes meiosis 1 = haploid secondary spermatocytes meiosis 2 = haploid spermatids
spermatids spermiogenesis (mature) = spermatozoa

mature sperm cell
- head: haploid nucleus covered by acrosome (proteases to digest corona radiata & zona pellucida)
- middle: mitochondria – ATP for movement
- tail/flagellum: lashing movements for motility



female reproductive system
2 ovaries
fallopian tubes – oviducts
uterus
- endometrium: innermost layer
o mucous membrane – good blood supply
o builds & sheds in menstruation + implantation
cervix: narrow ring of connective tissue & muscle
vagina: muscular – open at vulva

oogenesis = secondary oocytes – ovary

before birth in developing foetus
germinal epithelium mitosis = oogonia mitosis = primary oocytes meiosis 1 ~ prophase 1 until puberty
- surrounded by germinal epithelium mitosis = primary follicle

after puberty – each month
primary oocyte completes meiosis 1 = haploid secondary oocyte + haploid first polar body
(haploid: remove half chromosomes & small: leave most cytoplasm to oocyte)
FSH stimulates primary follicle to develop = secondary follicle = Graafian follicle (1 fully develops per month)
ovulation: Graafian follicle moves to ovary surface + bursts = releases secondary oocyte
secondary oocyte start meiosis 2 ~ stop at metaphase 2 unless fertilised
fertilised: secondary oocyte meiosis 2 = haploid ovum (fuse with sperm) + haploid second polar body
Graafian follicle = corpus luteum + produces progesterone
not: Graafian follicle regresses

secondary oocyte after ovulation
Corona radiata: surrounds – provides nutrients
Zona pellucida: surrounds cell membrane
First polar body extrudes from end
Cortical granules: in cytoplasm periphery – prevents polyspermy
Chromosomes & spindle apparatus from meiosis
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