Immunology lectures summary BSc Biomedical Sciences, 2021/2022

what is immunology? (3) - correct answers 1) study of host defense system 2) protect host from foreign substance/from itself 3) very diverse- defense against any invasion two broad branches of immunity - correct answers 1) innate -non specific response, effective against broad spectrum of immunological changes 2) adaptive -precise response; split into two sub branches a) humoral adaptive: B cell centered, antibodies primary effector, mature in bone marrow b) humoral cell mediated: T cell centered, cell primary effector, mature in thymus principles of innate immunity - correct answers -lack pathogen specific receptors (effective against most pathogen) *phagocyte: cells undergo phagocytosis -polymorphic neutrophils (PMN) -macrophages (mF) -dendritic cells (DC) -eosinophils *professional antigen presenting cell (pAPC): present antigen to Th cells for activation principles of adaptive immunity - correct answers -specificity *2 T cell classes (TCR) 1) Th (helper)= activates CMI, recognizes antigens for MHC Class II (pAPC) 2) Tc (cytotoxic)= kills problem cells; recognize antigens for MHC Class I (target cells)