ANTICANCER AGENTS
Onkar Salunke
,Alkylating Agents
The alkylating agents are a class of drugs that are
capable of forming covalent bonds with important
biomolecules.
The major targets of drug action are nucleophilic
groups present on DNA (especially the 7-position
of guanine);
, however, proteins and RNA among others may
also be alkylated.
Alkylation of DNA is thought to lead to cell death,
,
Onkar Salunke
,Alkylating Agents
The alkylating agents are a class of drugs that are
capable of forming covalent bonds with important
biomolecules.
The major targets of drug action are nucleophilic
groups present on DNA (especially the 7-position
of guanine);
, however, proteins and RNA among others may
also be alkylated.
Alkylation of DNA is thought to lead to cell death,
,
