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Orthopaedic and Trauma Medicine PHARMACOLOGY II Year: 2022 Semester: 2 Session 3

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Orthopaedic and Trauma Medicine PHARMACOLOGY II Y
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Cephalosporins • Have almost a similar structure to penicillins • Have variable antibacterial activity Mechanism of action • Inhibit cell wall synthesis • They are bactericidal Classification First generation cephalosporins Oral preps: Cephalexin, Cefadroxil, Cephazolin Injectables :Cephradine, cephazolin Second generation cephalosporins • Haemophilus active – cefuroxime, cefamandole, cefaclor • Bacteroides active – cefoxitin, cefotetan Third generation cephalosporins • Extended spectrum- ceftriaxone, cefotaxime, cefixime • Extended spectrum and antipseudomonal- ceftazidine, cephoperazone Fourth generation cephalosporins • Cefipime – Good activity against pseudomonas and enters csf.

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Kenya Medical Training College
Department of Orthopaedic and
Trauma Medicine
PHARMACOLOGY II
Year: 2022 Semester: 2
Session 3
Topic: Cephalosporins and
Aminoglycosides
th
Date: 12 April 2022
By: Carol Babu

,Cephalosporins

• Have almost a similar structure to
penicillins
• Have variable antibacterial activity

Mechanism of action
• Inhibit cell wall synthesis
• They are bactericidal

, Classification
❖ First generation cephalosporins
Oral preps: Cephalexin, Cefadroxil, Cephazolin

Injectables :Cephradine, cephazolin

❖ Second generation cephalosporins
• Haemophilus active – cefuroxime, cefamandole,
cefaclor

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  • trauma medicine pha
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  • orthopaedic and trauma medicine pharmacology ii
  • orthopaedic and trauma medicine pharmacology

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