PHYS Q3 Exam 3| QUESTIONS WITH COMPLETE SOLUTIONS

Insulin is made by what cells? Correct Answer: pancreatic B cells What is the precursor to proinsulin? Correct Answer: Preproinsulin What is the precursor to C peptide and insulin? Correct Answer: Proinsulin Where is proinsulin processed to insulin? Correct Answer: In secretory granules What is a good indicator of insulin levels in the body? Correct Answer: C peptide as a way to measure waste product of proinsulin How is insulin degraded? Correct Answer: Via proteases Where is GLP-1 found? Correct Answer: In the intestine Where is GLP-1 released and what does it do? Correct Answer: L cells in the gut lining —released after a meal Potentiates glucose induced insulin secretion Derived from the same gene as glucagon How is GLP-1 inactivated? Correct Answer: By: peptidase DPP4 which cleaves 2aa from GLP1 What do DPP4 inhibitors treat? Correct Answer: Type II diabetes Glucagon is produced from what? Correct Answer: Proglucagon protein What is glucagon processed by? Correct Answer: Pancreatic a cells by PC2 (PC is prohormone convertase) When is glucagon released? Correct Answer: In response to low blood glucose levels