N5315 Advanced Pathophysiology Inflammation, Altered Immunity and Infection Core Concepts Objectives with Advanced Organizers

Examine the structure and function of the immune system. a. Describe how the normal function of T-lymphocyte and B-lymphocyte cells differ. i. T Cells- Cell mediated immunity. 1. “cluster of differentiation” 2. CD4 cells- t-helper or t4 cells a. Release lymphokines to begin inflammatory process b. Mediate delayed sensitivity. (TB skin test). 3. CD8 cells aka t cells, killer t, and t8. a. Kill viruses by releasing cytotoxic chemicals 4. Memory T a. Remember the antigen and respond quicker and stronger after 1st exposure. 5. T Regulatory a. Slow or stop immune response once initiated. ii. B cells- humoral immunity. 1. Mature into plasma cells that produce antibodies. b. Differentiate between function of humoral and cell mediated immunity and describe the implications for practice. i. Humoral Immunity 1. B cells