PHARMACOLOGY MCQs WITH ALL THE ANSWERS LATEST UPDATE 2022

Of the many types of data plots that are used to help explain the pharmacodynamics of drugs, which plot is very useful for determining the total number of receptors and the affinity of those receptors in a tissue or membrane? a. Graded dose-response curve b. Quantal dose-respose curve c. Scatchard plot d. Double-reciprocalplot e. Michaelis-Menten plot 2. Which route of administration is most likely to subject a drug to a first-pass effct? a. Intravenous b. Inhalational c. Oral (And Rectal as well) d. Sublingual(S1) e. Intramuscular 3. Two drugs may act on the same tissue or organ through independent receptors,resulting in effects in opposite directions.This is known as a. Physiologic antagonism b. Chemical antagonism (Chemically two drugs combine) c. Competitive antagonism (Reversible binding to Receptor) d. Irreversible antagonism (Irreversible binding to Receptor) e. Dispositional antagonism (One drug alters pharmacokinetics of other drug, i.e. A,D,E,M) 4. If a drug is repeatedly administered at dosing intervals that are equal to its elimination half-life,the number of doses required for the plasma concentration of the drug to reach the steady state is a. 2 to 3 b. 4 to 5 c. 6 to 7 d. 8 to 9 e. 10 or more 5.The pharmacokinetic value that most reliably reflects the amount of drug reaching the target tissue after oral administration is the a.Peak blood concentration b.Time to peak blood concentration c.Product of the Vd and the first –order rate constant d. Vd e.Area under the blood concentrate-time curve(AUC)