Impact of Diet in Cancer
Three major subtopics
Obesity/Caloric restriction
Hypermethylation of DNA
Flavonoids and Carotenoids
Obesity is associated with hormonal based cancers e.g., breast, prostate, endometrial, colon and gall
bladder.
Calle, E.E. and Thun, M.J. (2004) Obesity and cancer. Oncogene, 23 (38), 6365-6378.
Discusses links between specific compounds e.g., insulin or IGF-1 to cancer caused by obesity/diet,
also discusses specific cancers.
Arnold, M., Leitzmann, M., Freisling, H., Bray, F., Romieu, I., Renehan, A. and Soerjomataram, I.
(2016) Obesity and cancer: An update of the global impact. Cancer Epidemiology, 41, 8-15.
Review of modern diets and global obesity crisis – also discusses the issues linked with cancer
survivors because of early detection and better medication but are overweight causing comorbidities
and issues with wound healing – need for better guidance after cancer to help obese patients
recover.
Rapp, K., Schroeder, J., Klenk, J., Stoehr, S., Ulmer, H., Concin, H., Diem, G., Oberaigner, W. and
Weiland, S.K. (2005) Obesity and incidence of cancer: a large cohort study of over 145 000 adults in
Austria. British Journal of Cancer, 93 (9), 1062-1067.
Study of men and women in Austria between 1985 and 2002 – 145,931 people were analysed, 6241
patients developed cancer in that time – a positive linear correlation was seen in men between colon
cancer and increased BMI.
Ohtani, N., Yoshimoto, S. and Hara, E. (2014) Obesity and Cancer: A Gut Microbial Connection.
Cancer Research, 74 (7), 1885-1889.
Remarkably interesting – links gut microbiota changes due to obesity to cancer cause on a molecular
level – although it is a mouse study.
Cleary, M.P. and Grossmann, M.E. (2009) Obesity and Breast Cancer: The Estrogen Connection.
Endocrinology, 150 (6), 2537-2542.
Good for understanding but probably find better sources on the day.
Caloric restriction – found to have reduced IGF (insulin like growth factor), enhancement of
apoptosis and anti-angiogenesis properties, possible inhibition of IGF-1 and mTORC
Okinawa diet –
Tsubono, Y., Tsugane, S. and Gey, K.F. (1999) Plasma Antioxidant Vitamins and Carotenoids in Five
Japanese Populations With Varied Mortality From Gastric Cancer. Nutrition and Cancer, 34 (1), 56-
61. – discusses diet e.g., flavonoids and β-carotene in 5 different Japanese populations.
Tamaki, K., Tamaki, N., Terukina, S., Kamada, Y., Uehara, K., Arakaki, M., Miyashita, M., Ishida, T.,
McNamara, K.M., Ohuchi, N. and Sasano, H. (2014) The Correlation between Body Mass Index and
Three major subtopics
Obesity/Caloric restriction
Hypermethylation of DNA
Flavonoids and Carotenoids
Obesity is associated with hormonal based cancers e.g., breast, prostate, endometrial, colon and gall
bladder.
Calle, E.E. and Thun, M.J. (2004) Obesity and cancer. Oncogene, 23 (38), 6365-6378.
Discusses links between specific compounds e.g., insulin or IGF-1 to cancer caused by obesity/diet,
also discusses specific cancers.
Arnold, M., Leitzmann, M., Freisling, H., Bray, F., Romieu, I., Renehan, A. and Soerjomataram, I.
(2016) Obesity and cancer: An update of the global impact. Cancer Epidemiology, 41, 8-15.
Review of modern diets and global obesity crisis – also discusses the issues linked with cancer
survivors because of early detection and better medication but are overweight causing comorbidities
and issues with wound healing – need for better guidance after cancer to help obese patients
recover.
Rapp, K., Schroeder, J., Klenk, J., Stoehr, S., Ulmer, H., Concin, H., Diem, G., Oberaigner, W. and
Weiland, S.K. (2005) Obesity and incidence of cancer: a large cohort study of over 145 000 adults in
Austria. British Journal of Cancer, 93 (9), 1062-1067.
Study of men and women in Austria between 1985 and 2002 – 145,931 people were analysed, 6241
patients developed cancer in that time – a positive linear correlation was seen in men between colon
cancer and increased BMI.
Ohtani, N., Yoshimoto, S. and Hara, E. (2014) Obesity and Cancer: A Gut Microbial Connection.
Cancer Research, 74 (7), 1885-1889.
Remarkably interesting – links gut microbiota changes due to obesity to cancer cause on a molecular
level – although it is a mouse study.
Cleary, M.P. and Grossmann, M.E. (2009) Obesity and Breast Cancer: The Estrogen Connection.
Endocrinology, 150 (6), 2537-2542.
Good for understanding but probably find better sources on the day.
Caloric restriction – found to have reduced IGF (insulin like growth factor), enhancement of
apoptosis and anti-angiogenesis properties, possible inhibition of IGF-1 and mTORC
Okinawa diet –
Tsubono, Y., Tsugane, S. and Gey, K.F. (1999) Plasma Antioxidant Vitamins and Carotenoids in Five
Japanese Populations With Varied Mortality From Gastric Cancer. Nutrition and Cancer, 34 (1), 56-
61. – discusses diet e.g., flavonoids and β-carotene in 5 different Japanese populations.
Tamaki, K., Tamaki, N., Terukina, S., Kamada, Y., Uehara, K., Arakaki, M., Miyashita, M., Ishida, T.,
McNamara, K.M., Ohuchi, N. and Sasano, H. (2014) The Correlation between Body Mass Index and
