NURS 3460 Antilipemic and Hematology Medication Table - 2021 | UPDATED

NURS 3460 Antilipemic and Hematology Medication Table - 2021 Antilipemic and Hematology Medication Table This table will make you able to “Go with your GUT ASAP!” Group / Class (Prototype) Use Therapeutic Effects Adverse Effects Safety Concerns Administrati on Patient Education HMG-Coa Reductase Inhibitors: - Simvastati n (Simvastati n and ezetimibe combinatio n) - Atorvastati n - Lovastatin One of the most widely used drugs in the U.S.; most powerful for reducing LDL Decrease LDL, VLDL, & triglycerides; increase HDL; other benefits Primary hypercholestere mia, prevention of coronary events, MI protection for DM One of the most widely used drugs in the U.S.; most powerful for reducing LDL Decrease LDL, VLDL, & triglycerides; increase HDL; other benefits Primary hypercholestere mia, prevention of coronary events, MI protection for DM • Hepatotoxicit y: baseline and monitor AST; report symptoms; avoid alcohol • Myopathy (muscle aches, tenderness): can lead to myositis or rhabdomyolys is; risk for older/frail clients; baseline and monitor CK; report symptoms • Contraindicated for pregnancy, lactation, liver disorder – Contraceptive s – Caution for previous liver disease – Dose reduction for severe kidney impairment Interactions: • Fibrates & ezetimibe increase risk for myopathy/kidney injury • CYP3A4 medications, HIV protease inhibitors, amiodarone, cyclosporine: increase statin levels • Grapefruit juice: increase statin levels Lovastatin with evening meal, others without regard to food but at night Orally • Report symptoms of hepatotoxicity (jaundice, anorexia, N/V) • Avoid alcohol • Report muscle pain • Use contraception • Discuss other medications • Avoid grapefruit Keep up with lab work