Year 3 Week 6 Physiology
Molecular Biology of Muscle Adaptation
What is molecular exercise physiology?
“Study of exercise at the molecular level which aims to identify an uninterrupted sequence of
events which starts with the signals associated with exercise and ends in a specific adaptive
response” (p. 122)
Exercise Induced Adaptation
Depends on nature of activity:
Endurance Activity
● Fatigue resistance
● Greater proportion of type 1 fibres
● Mitochondrial network
● Enhanced fatty acid oxidation
Resistance Activity
● Selective myofibre hypertrophy
● Protein accretion (anabolic stimulus)
Central dogma of molecular biology
DNA
, Gene Transcription
Gene Translation
Molecular Biology of Muscle Adaptation
What is molecular exercise physiology?
“Study of exercise at the molecular level which aims to identify an uninterrupted sequence of
events which starts with the signals associated with exercise and ends in a specific adaptive
response” (p. 122)
Exercise Induced Adaptation
Depends on nature of activity:
Endurance Activity
● Fatigue resistance
● Greater proportion of type 1 fibres
● Mitochondrial network
● Enhanced fatty acid oxidation
Resistance Activity
● Selective myofibre hypertrophy
● Protein accretion (anabolic stimulus)
Central dogma of molecular biology
DNA
, Gene Transcription
Gene Translation
