PHARM NR 293 Pharmacology Final Exam Review

Pharmacology Final Exam Review 1. Review primary, secondary hypothyroidism, and the causes. - Hypothyroidism  Primary hypothyroidism: abnormality of the thyroid gland itself. It occurs when the thyroid gland is not able to perform one of its ma functions, such as releasing the thyroid hormones from their storage sites, coupling iodine with tyrosine, trapping iodide, converting iodide to iodine, or any combination of the defects. This version is the most common  Secondary hypothyroidism: begins at the level of the pituitary gland and results from the reduced secretion of TSH. TSH is needed to trigger the release of T3 and T4 stored in the thyroid gland.  Tertiary hypothyroidism: caused by reduced level of thyrotropin-releasing hormone from the hypothalamus. This then reduces TSH and thyroid hormone levels  Signs and symptoms of hypothyroidism: cold-intolerance, unintentional weight gain, depression, dry brittle hair and nails, and fatigue