BSC 2346 Module 4 Case Study

BSC 2346 Module 4 Case Study.• Question 1 1 out of 1 points Jordan is now 19-years old. As an infant, Jordan reached many gross motor skill milestones, such as holding his head up, rolling over, sitting, and standing, at normal times. However, he was considered a “late walker” because he took his first steps at 17 months. By 2 years old, his parents noticed a hyperlordotic posture while he was standing. A Gower's sign and Trendelenberg gait were noted by age four. Throughout his childhood, he suffered progressive muscle weakness, especially in the proximal musculature of the arms, pelvis, and legs. He required orthotic braces to assist his walking and was confined to wheelchair ambulation by age 13. At 16, he was hospitalized with bronchitis requiring antibiotic treatment, but recovered. Jordan has a history of progressive muscle weakness, but no history of muscle pain or spasm, chest pain, or irregular heartbeat. The only medications that he normally takes are calcium and fluoride supplements. Jordan has three siblings. His older and younger sisters have never had any major medical issues. Jordan’s older brother is also to a wheelchair with problems similar to Jordan's. No other immediate or distant family members have musculoskeletal issues. Jordan’s history aligns most closely with which diagnosis? Selected Answer: Duchenne muscular dystrophy • Question 2 1 out of 1 points Jordan had a biopsy of the left gastrocnemius muscle when he was 5 years old. Based on your answer for his diagnosis, describe the microscopic pathological changes that the pathologist would have noted in her report. Selected Answer: The pathologist would have noted in her report the changes in the muscle tissue such as marked variation in myofiber size, with small, atrophic fibers admixed with large, rounded hyphertropic ones, the myofiber splitting, necrosis, and regeneration, Architectural changes (whorled fibers, moth eaten fibers) may be seen. Response Feedback: [None Given] • Question 3 0.5 out of 1 points Explain, in your own words, why Jordan’s brother appears to have the same disease and why his sisters are unaffected. Selected Answer: Jordan's brother appears to have the same disease as Jordan because they both have Duchenne muscular dystrophy which is a inherited disorder that typically occurs in boys. Response Feedback: You had to be more specific and state it is related to the x-chromosome. Duchenne muscular dystrophy (DMD) is a progressive form of muscular dystrophy that occurs primarily in males. Genetic changes causing Duchenne muscular dystrophy (DMD) can be passed down in families. The DMD gene is located on the X chromosome, one of the two types of sex chromosomes. Males have an X and a Y chromosome; whereas females have two X chromosomes.