NR 546
Final Exam 2026 | Practice & Prediction Questions
with Answers and Rationales | Complete Study Guide
RESOURCE FEATURES
• NR 546 Final Exam practice questions
• Prediction-style review questions
• Answers for self-assessment
• Detailed rationales and explanations
• Clinical scenario-based practice
• Priority and clinical-judgment questions
• Key-concept review
• Graduate nursing exam preparation
• 2026-focused study material
, NR 546 Final Exam 2026 | Practice &
Prediction Questions with Answers and
Rationales | Complete Study Guide
Question 1
MAOIs (monoamine oxidase inhibitors) affect which neurotransmitters?
A. Serotonin, Dopamine, Norepinephrine
B. Serotonin, GABA, Glutamate
C. Acetylcholine, Dopamine, Norepinephrine
D. Dopamine, GABA, Acetylcholine
Answer: A. Serotonin, Dopamine, Norepinephrine
Rationale: MAOIs inhibit the enzyme monoamine oxidase, which breaks
down serotonin, dopamine, and norepinephrine, thereby increasing their
availability in the synaptic cleft.
Question 2
Which of the following is considered first line treatment for depression?
A. SSRI
B. FGA
,C. SNRI
D. MAOI
Answer: A. SSRI
Rationale: SSRIs (Selective Serotonin Reuptake Inhibitors) are considered
first-line treatment for depression due to their favorable side effect profile
and efficacy.
Question 3
When treating a patient for major depression disorder which medication
would the PMHNP consider first?
A. Depakote
B. Selegiline
C. Escitalopram
D. Isocarboxazid
Answer: C. Escitalopram
Rationale: Escitalopram is an SSRI and is considered a first-line treatment
for major depressive disorder.
Question 4
Which of the following medication should be considered for a patient
diagnosed with major depressive disorder who reports "always forgetting
to take my pills"?
, A. Mirtazapine
B. Fluvoxamine
C. Fluoxetine
D. Carbamazepine
Answer: C. Fluoxetine
Rationale: Fluoxetine has a long half-life (approximately 2-4 days), making
it more forgiving if a dose is missed.
Question 5
Which of the following medication has a black box warning of a life-
threatening skin rash?
Answer: Lamotrigine
Rationale: Lamotrigine carries a black box warning for Stevens-Johnson
syndrome and toxic epidermal necrolysis, life-threatening skin rashes.
Question 6
Which medication is considered the best tolerated SSRI?
A. Venlafaxine
B. Bupropion
C. Sertraline
D. Escitalopram
Answer: D. Escitalopram
Final Exam 2026 | Practice & Prediction Questions
with Answers and Rationales | Complete Study Guide
RESOURCE FEATURES
• NR 546 Final Exam practice questions
• Prediction-style review questions
• Answers for self-assessment
• Detailed rationales and explanations
• Clinical scenario-based practice
• Priority and clinical-judgment questions
• Key-concept review
• Graduate nursing exam preparation
• 2026-focused study material
, NR 546 Final Exam 2026 | Practice &
Prediction Questions with Answers and
Rationales | Complete Study Guide
Question 1
MAOIs (monoamine oxidase inhibitors) affect which neurotransmitters?
A. Serotonin, Dopamine, Norepinephrine
B. Serotonin, GABA, Glutamate
C. Acetylcholine, Dopamine, Norepinephrine
D. Dopamine, GABA, Acetylcholine
Answer: A. Serotonin, Dopamine, Norepinephrine
Rationale: MAOIs inhibit the enzyme monoamine oxidase, which breaks
down serotonin, dopamine, and norepinephrine, thereby increasing their
availability in the synaptic cleft.
Question 2
Which of the following is considered first line treatment for depression?
A. SSRI
B. FGA
,C. SNRI
D. MAOI
Answer: A. SSRI
Rationale: SSRIs (Selective Serotonin Reuptake Inhibitors) are considered
first-line treatment for depression due to their favorable side effect profile
and efficacy.
Question 3
When treating a patient for major depression disorder which medication
would the PMHNP consider first?
A. Depakote
B. Selegiline
C. Escitalopram
D. Isocarboxazid
Answer: C. Escitalopram
Rationale: Escitalopram is an SSRI and is considered a first-line treatment
for major depressive disorder.
Question 4
Which of the following medication should be considered for a patient
diagnosed with major depressive disorder who reports "always forgetting
to take my pills"?
, A. Mirtazapine
B. Fluvoxamine
C. Fluoxetine
D. Carbamazepine
Answer: C. Fluoxetine
Rationale: Fluoxetine has a long half-life (approximately 2-4 days), making
it more forgiving if a dose is missed.
Question 5
Which of the following medication has a black box warning of a life-
threatening skin rash?
Answer: Lamotrigine
Rationale: Lamotrigine carries a black box warning for Stevens-Johnson
syndrome and toxic epidermal necrolysis, life-threatening skin rashes.
Question 6
Which medication is considered the best tolerated SSRI?
A. Venlafaxine
B. Bupropion
C. Sertraline
D. Escitalopram
Answer: D. Escitalopram
