NURS 6521 Exam 1 | NURS 6521 Advanced
Pathophysiology II | Actual Q&A with Rationale
(NURS 6521 Exam 1) | Walden
Exam 1
Instructions:
This exam consists of two sections.
Section A: Multiple choice (40 questions). Select the best answer for each.
Section B: Case-based questions (10 questions).
Section A: Multiple Choice (40 questions)
Q1. Which cellular adaptation involves an increase in cell size due to increased
workload?
A. Hyperplasia
B. Hypertrophy ✅
C. Atrophy
D. Metaplasia
Rationale: Hypertrophy is an increase in cell size, not number, often in response to
increased demand (e.g., cardiac hypertrophy).
Q2. Which type of mutation involves a single base pair change that leads to a
premature stop codon?
A. Missense
B. Nonsense ✅
C. Frameshift
D. Silent
, Rationale: Nonsense mutation creates a stop codon, truncating the proten.
Q3. The p53 tumor suppressor gene is often mutated in cancer. Its normal function
is to:
A. Promote cell division
B. Induce apoptosis or cell cycle arrest in damaged cells ✅
C. Activate oncogenes
D. Inhibit DNA repair
Rationale: p53 prevents propagation of damaged cells by stopping the cell cycle or
triggering apoptosis.
Q4. Which type of inheritance pattern is seen in Huntington’s disease?
A. Autosomal recessive
B. Autosomal dominant ✅
C. X-linked recessive
D. Mitochondrial
Rationale: Huntington’s is caused by a dominant mutation on chromosome 4.
Q5. The mechanism of action of a monoclonal antibody used to block TNF-α is:
A. Agonist at TNF receptor
B. Antagonist that binds and neutralizes TNF-α ✅
C. Enzyme inhibitor
D. Receptor activator
Rationale: Monoclonal antibodies like infliximab bind TNF-α, preventing it from
activating its receptor.
Q6. Which type of hypersensitivity reaction is mediated by T cells and results in
delayed response (e.g., tuberculin skin test)?
Pathophysiology II | Actual Q&A with Rationale
(NURS 6521 Exam 1) | Walden
Exam 1
Instructions:
This exam consists of two sections.
Section A: Multiple choice (40 questions). Select the best answer for each.
Section B: Case-based questions (10 questions).
Section A: Multiple Choice (40 questions)
Q1. Which cellular adaptation involves an increase in cell size due to increased
workload?
A. Hyperplasia
B. Hypertrophy ✅
C. Atrophy
D. Metaplasia
Rationale: Hypertrophy is an increase in cell size, not number, often in response to
increased demand (e.g., cardiac hypertrophy).
Q2. Which type of mutation involves a single base pair change that leads to a
premature stop codon?
A. Missense
B. Nonsense ✅
C. Frameshift
D. Silent
, Rationale: Nonsense mutation creates a stop codon, truncating the proten.
Q3. The p53 tumor suppressor gene is often mutated in cancer. Its normal function
is to:
A. Promote cell division
B. Induce apoptosis or cell cycle arrest in damaged cells ✅
C. Activate oncogenes
D. Inhibit DNA repair
Rationale: p53 prevents propagation of damaged cells by stopping the cell cycle or
triggering apoptosis.
Q4. Which type of inheritance pattern is seen in Huntington’s disease?
A. Autosomal recessive
B. Autosomal dominant ✅
C. X-linked recessive
D. Mitochondrial
Rationale: Huntington’s is caused by a dominant mutation on chromosome 4.
Q5. The mechanism of action of a monoclonal antibody used to block TNF-α is:
A. Agonist at TNF receptor
B. Antagonist that binds and neutralizes TNF-α ✅
C. Enzyme inhibitor
D. Receptor activator
Rationale: Monoclonal antibodies like infliximab bind TNF-α, preventing it from
activating its receptor.
Q6. Which type of hypersensitivity reaction is mediated by T cells and results in
delayed response (e.g., tuberculin skin test)?
