Questions | Graded A+
1. What is the first phase of drug development?
Post-marketing surveillance
Phase II
Preclinical testing
Phase I
2. Ankylosing spondylitis is _.
fusion or stiffness of the vertebrae with inflammation
a narrowing of the spinal canal causing pressure on the cord and
nerves
inflammation of the ankle joint with stiffness
an abnormal lateral curvature of the spine
3. The patient recently diagnosed with asthma asks the nurse what type of
medication is usually used to manage the disease. Which response by the
nurse is correct?
"Antihistamines are the most common drug used for asthma."
"Liquefying agents are the first-line drugs used to treat asthma."
"Antiviral agents are used most often."
"Bronchodilators are the most frequently used medication."
4. If a patient is started on warfarin therapy, what should be monitored to
ensure the medication is effective and safe?
, Liver function tests
Complete blood count
Blood glucose levels
INR (International Normalized Ratio)
5. Which class of medications is commonly used to treat heart failure by helping
to reduce fluid overload?
Aldosterone antagonists
ACE inhibitors
Diuretics
Beta-blockers
6. In Hirschsprung's disease, the migration of the myenteric plexus and
submucosal plexus is not complete, and the distal part of the colon lacks
ganglion cells resulting in persistent overstimulation. What is the expected
clinical presentation?
A 5-year-old male presenting with abdominal pain and only having
bowel movements every 3-5 days.
A 65-year-old female presenting with loose stools, urgency, and fecal
incontinence.
A 35-year-old female presenting with difficulty passing stools and
inadequate emptying of the rectum after bowel movements.
A 4-day-old male presenting with no bowel movements since birth
and abdominal distention.
7. What is the definition of drug absorption in pharmacokinetics?
, Absorption is the process by which a drug moves from the
administration site into the blood or plasma.
Absorption is the breakdown of a drug into its metabolites.
Absorption is the elimination of a drug from the body.
Absorption is the distribution of a drug throughout the body's tissues.
8. What is the effect of omeprazole on clopidogrel's activation?
It inhibits the enzymatic conversion of clopidogrel to its active
metabolite.
It enhances the absorption of clopidogrel in the stomach.
It has no effect on clopidogrel's activation.
It increases the metabolism of clopidogrel to its inactive form.
9. What are the possible routes of administration for nitroglycerin?
Only orally and intravenously
Orally, intramuscularly, or rectally
Sublingually and orally
IV, sublingually, topically, or transdermally
10. Describe the significance of the absorption phase in pharmacokinetics and
its impact on drug efficacy.
The absorption phase is crucial as it determines how quickly and
effectively a drug enters the bloodstream, influencing its
therapeutic effects.
The absorption phase is the same as the elimination phase in
pharmacokinetics.
, The absorption phase is unimportant since all drugs are immediately
effective upon administration.
The absorption phase only affects the side effects of a drug, not its
efficacy.
11. What are the components of the recommended treatment for severe
persistent asthma?
A long-acting beta-2 agonist (LABA), a high-potency inhaled
corticosteroid, and an oral corticosteroid.
A long-acting beta-2 agonist and a short-acting beta-2 agonist.
An inhaled corticosteroid and a leukotriene receptor antagonist.
A short-acting beta-2 agonist and an antihistamine.
12. What is osteoporosis?
Loss of bone mass and strength
High blood sugar
Loss of muscle mass and strength
High blood pressure
13. Metabolism is the •chemical change of drug structure to:
enhance excretion
inactivate the drug
increase therapeutic action
activate a prodrug
increase or decrease toxicity
all of the above