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USMLE Step 1 Exam Prep 2026 | Practice Questions with Answers & Explanations | First Aid Study Guide

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Prepare for the USMLE Step 1 with a comprehensive exam-preparation resource featuring practice questions, answers, and explanations designed to reinforce high-yield medical concepts. The resource complements First Aid for the USMLE Step 1, 36th Edition by Tao Le and Vikas Bhushan, the 2026 edition published by McGraw Hill. The official edition includes more than 1,000 clinical images, 1,300+ high-yield facts and mnemonics, and updated Step 1 preparation guidance. Key areas covered include: Biochemistry Immunology Microbiology Pathology Pharmacology Physiology Anatomy and embryology Cardiovascular system Endocrine system Gastrointestinal system Hematology and oncology Musculoskeletal system Neurology and psychiatry Renal system Reproductive system Respiratory system High-yield clinical concepts USMLE-style practice questions and explanations

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1
Usmle




Usmle Step 1 First Aid Exam
Questions with Correct Verified
Solutions 100% Guaranteed Pass
Hypersensitivity vasculitis associated with hemorrhagic urticaria and
upper respiratory tract infections - diagnosis? - ANS ✓henoch-schonlein
purpura


Most common tumor of infancy - ANS ✓hemangioma



Charcot's triad of multiple sclerosis - ANS ✓nystagmus, intention
tremor, scanning speech (where the same emphasis is put on each syllable
like scanning a poem)


Most common causes of dic - ANS ✓gram-negative sepsis, obstetric
complications, cancer, burn trauma


Most common cause of myocarditis - ANS ✓coxsackie b



Kussmaul hyperpnea - diagnosis? - ANS ✓diabetic ketoacidosis



Lisch nodules - diagnosis? - ANS ✓neurofibromatosis (von
recklinghausen's disease)


Polyneuropathy, cardiac pathology, and edema - diagnosis?

Usmle Step 1 First Aid

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Usmle

- what causes it? - ANS ✓wet beriberi (vitamin b1 deficiency)


Most common malignancy associated with noninfectious fever - ANS
✓Hodgkin’s disease



Port-wine stain - diagnosis? - ANS ✓hemangioma


What is trousseau's sign of malignancy?

- possible diagnoses? - ANS ✓migratory thrombophlebitis
- visceral cancer or pancreatic adenocarcinoma


Homer wright rosettes - diagnosis? - ANS ✓neuroblastoma


What is trousseau's sign of latent tetany?

- diagnosis? - ANS ✓carpal spasm
- hypocalcemia


What is Virchow’s triad?

- predilection for what? - ANS ✓blood stasis, endothelial damage,
hypercoagulation
- pulmonary embolism


What is von recklinghausen's disease of bone? - ANS ✓osteitis fibrosa
cystica ("brown tumor")




Usmle Step 1 First Aid

, 3
Usmle

Adrenal hemorrhage associated with meningococcemia - diagnosis? -
ANS ✓waterhouse-friderichsen syndrome


Most common cause of hemochromatosis

- causes risk of? - ANS ✓multiple blood transfusions
- can cause chf and increased risk of hepatocellular carcinoma


Mechanism of action of macrolides and clindamycin? - ANS ✓bind 50s
subunit and block translocation


Most common cause of congenital adrenal hyperplasia - ANS ✓21-
hydroxylase deficiency


Most common tumor of the adrenal medulla in kids

- benign or malignant? - ANS ✓neuroblastoma - malignant



Most common cause of siadh - ANS ✓small cell carcinoma of the lung


Most common cause of cushing's syndrome

- 2nd most common? - ANS ✓corticosteroid therapy
- excess acth secretion by pituitary is 2nd


Most common cause of hypopituitarism - ANS ✓adenoma



Suboccipital lymphadenopathy - diagnosis? - ANS ✓rubella




Usmle Step 1 First Aid

, 4
Usmle

Most common vasculitis
- poses risk for?

- what causes this? - ANS ✓temporal arteritis
- risk of ipsilateral blindness - due to thrombosis of opthalmic artery


Most common cause of hepatocellular carcinoma - ANS ✓cirrhotic liver,
often due to hepatitis b and c


Most common cause of viral encephalitis - ANS ✓hsv


What is the defect in chediak-higashi syndrome?

- symptoms? - ANS ✓defect in microtubule polymerization, causing
decreased phagocytosis
- symptoms: recurrent pyogenic infections, partial albinism,
peripheral neuropathy


Most common cause of addison's

- 2nd most common? - ANS ✓autoimmune
- infection is 2nd


"smudge cell" - diagnosis? - ANS ✓cll



Most common cause of constrictive pericarditis - ANS ✓tuberculosis



Soap bubble on x-ray - diagnosis? - ANS ✓giant cell tumor of bone




Usmle Step 1 First Aid

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August 13, 2026
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