ABIM REVIEW EXAM TEST BANK 1,000+ HIGH-YIELD
PRACTICE QUESTIONS & VERIFIED ANSWERS
COMPREHENSIVE STUDY GUIDE (2026)
What vitamin deficiency can occur with use of Isoniazid (INH)?
- answer-Vitamin B6 (Pyridoxine)
What is the recommendation for initial colonoscopy after inflammatory
bowel disease diagnosis and follow up colonoscopies?
- answer-8 years after diagnosis and then every 1-2 years
If patient with inflammatory bowel disease is found to have dysplasia on
colonoscopy, what is the next step in management?
- answer-Proctocolectomy
What is the rash that is commonly associated with celiac disease?
- answer-Dermatitis herpetiformis
Which hepatitis infection is the only type that is a DNA virus?
- answer-Hepatitis B
Digestion of which toxin from reef fish can cause for peri-oral parasthesias
to occur?
- answer-Ciguatera toxin
Patient is found to have positive antibodies to soluble liver antigen (SLA).
What condition does this patient likely have?
- answer-Autoimmune hepatitis (which also has anti-smooth muscle
antibodies)
Treatment of MALT requires eradication of what organism?
- answer-Heliobacter Pylori (H. pylori)
,Long term use of NSAIDS increases, decreases, or has no effect on the risk
of developing colon cancer?
- answer-Decreases
Foamy macrophages on PAS stain on a small bowel biopsy is seen in what
condition?
- answer-Whipple's Disease
Ascitic fluid containing polymorphonuclear leukocytes (PMNs) greater than
this number indicates spontaneous bacterial peritonitis (SBP)?
- answer-Greater than 250/mm3
What is the simplest test to differentiate anemia of chronic disease from iron
deficiency?
- answer-Total iron-binding capacity (TIBC)
Along with homocysteine, what levels can be elevated with vitamin B12
deficiency?
- answer-Methylmalonic acid levels
Which antibody is associated with cold agglutinin hemolytic anemia?
- answer-IgM
Which vitamin is used to enhance iron absorption?
- answer-Vitamin C (Ascorbic acid)
Besides elevated MCV, what else can be elevated with folate deficiency?
- answer-Homocysteine levels
What environmental exposure can lead to acute vitamin B12 deficiency?
- answer-Nitrous oxide
Peripheral blood showing smudge cells is most specifically associated with
what condition?
- answer-Chronic Lymphocytic Leukemia (CLL)
What hematologic condition is often associated with restless leg syndrome?
- answer-Iron deficiency anemia
,Name three conditions that are very often associated with
hypogammaglobulinemia
- answer-CLL, nephrotic syndrome, bronchiectasis
What mutation is often associated with polycythemia vera?
- answer-JAK2 mutation
Which two CD markers are often deficient in individuals with paroxsysmal
nocturnal hemoglobinuria? (PNH)
- answer-CD55 and CD59
What are the most common vitamin K dependent clotting factors?
- answer-Factors II, VII, IX, and X
What is the earliest lab value to increase after repleting iron in patients with
iron deficiency anemia?
- answer-Reticulocyte count
What is the fundoscopic exam finding often seen with idiopathic intracranial
hypertension (Pseudotumor cerebri)?
- answer-Papilledema
What is the ideal LDL goal in CAD patients or CAD equvialent patients?
- answer-Less than 70 mg/dl
What is the inheritance pattern for Hereditary Hemorrhagic Telangiectasia
(HHT)?
- answer-Autosomal dominant. HHT is also known as Osler-Weber-
Randau syndrome
What is the most common symptom of Hereditary Hemorrhagic
Telangiectasia (HHT)?
- answer-Epistaxis (nose bleeding)
What are the possible agents for treating hypertension in pregnant women?
- answer-Hydralazine, Labetalol, Alpha methyldopa
Which pain medication should be avoided in patients who are taking SSRIs
for depression?
, - answer-Tramadol (concurrent use of SSRI with tramadol can cause
serotonin syndrome)
On fundoscopic examination, which condition is associated with cherry red
spots of the macula?
- answer-Retinal artery occlusion
Which disease is associated with decreased uroporphyringoen
decarboxylase activity?
- answer-Porphyria cutanea tarda
Best next step after pt has tried NSAIDs / OCPs for primary dymenorrhea
but symptoms persist >3 months?
- answer-Ultrasound to rule out uterine abnormalities like fibroids
What is the anti-depressant category of choice in patients with bulemia?
- answer-SSRIs
What is the main anti-depressant to be avoided in patients with seizure
disorder?
- answer-Buproprion
Anaphlyaxis reaction is an example of which type of hypersensitivity
reaction?
- answer-Type 1 hypersensitivity reaction
Which class of anti-depressants are associated with widened QRS complex
that can be treated with bicarbonate?
- answer-Tricyclic antidepressants (TCAs)
Which statin is the drug of choice in HIV patients?
- answer-Pravastatin
Within what age range does USPSTF recommend one-time screening for
AAA in men with a smoking history?
- answer-65 to 75 years
Name the supplement: Sleep aid also used for stress/anxiety relief. If
combined with EtOH, can oversedate.
- answer-Kava
PRACTICE QUESTIONS & VERIFIED ANSWERS
COMPREHENSIVE STUDY GUIDE (2026)
What vitamin deficiency can occur with use of Isoniazid (INH)?
- answer-Vitamin B6 (Pyridoxine)
What is the recommendation for initial colonoscopy after inflammatory
bowel disease diagnosis and follow up colonoscopies?
- answer-8 years after diagnosis and then every 1-2 years
If patient with inflammatory bowel disease is found to have dysplasia on
colonoscopy, what is the next step in management?
- answer-Proctocolectomy
What is the rash that is commonly associated with celiac disease?
- answer-Dermatitis herpetiformis
Which hepatitis infection is the only type that is a DNA virus?
- answer-Hepatitis B
Digestion of which toxin from reef fish can cause for peri-oral parasthesias
to occur?
- answer-Ciguatera toxin
Patient is found to have positive antibodies to soluble liver antigen (SLA).
What condition does this patient likely have?
- answer-Autoimmune hepatitis (which also has anti-smooth muscle
antibodies)
Treatment of MALT requires eradication of what organism?
- answer-Heliobacter Pylori (H. pylori)
,Long term use of NSAIDS increases, decreases, or has no effect on the risk
of developing colon cancer?
- answer-Decreases
Foamy macrophages on PAS stain on a small bowel biopsy is seen in what
condition?
- answer-Whipple's Disease
Ascitic fluid containing polymorphonuclear leukocytes (PMNs) greater than
this number indicates spontaneous bacterial peritonitis (SBP)?
- answer-Greater than 250/mm3
What is the simplest test to differentiate anemia of chronic disease from iron
deficiency?
- answer-Total iron-binding capacity (TIBC)
Along with homocysteine, what levels can be elevated with vitamin B12
deficiency?
- answer-Methylmalonic acid levels
Which antibody is associated with cold agglutinin hemolytic anemia?
- answer-IgM
Which vitamin is used to enhance iron absorption?
- answer-Vitamin C (Ascorbic acid)
Besides elevated MCV, what else can be elevated with folate deficiency?
- answer-Homocysteine levels
What environmental exposure can lead to acute vitamin B12 deficiency?
- answer-Nitrous oxide
Peripheral blood showing smudge cells is most specifically associated with
what condition?
- answer-Chronic Lymphocytic Leukemia (CLL)
What hematologic condition is often associated with restless leg syndrome?
- answer-Iron deficiency anemia
,Name three conditions that are very often associated with
hypogammaglobulinemia
- answer-CLL, nephrotic syndrome, bronchiectasis
What mutation is often associated with polycythemia vera?
- answer-JAK2 mutation
Which two CD markers are often deficient in individuals with paroxsysmal
nocturnal hemoglobinuria? (PNH)
- answer-CD55 and CD59
What are the most common vitamin K dependent clotting factors?
- answer-Factors II, VII, IX, and X
What is the earliest lab value to increase after repleting iron in patients with
iron deficiency anemia?
- answer-Reticulocyte count
What is the fundoscopic exam finding often seen with idiopathic intracranial
hypertension (Pseudotumor cerebri)?
- answer-Papilledema
What is the ideal LDL goal in CAD patients or CAD equvialent patients?
- answer-Less than 70 mg/dl
What is the inheritance pattern for Hereditary Hemorrhagic Telangiectasia
(HHT)?
- answer-Autosomal dominant. HHT is also known as Osler-Weber-
Randau syndrome
What is the most common symptom of Hereditary Hemorrhagic
Telangiectasia (HHT)?
- answer-Epistaxis (nose bleeding)
What are the possible agents for treating hypertension in pregnant women?
- answer-Hydralazine, Labetalol, Alpha methyldopa
Which pain medication should be avoided in patients who are taking SSRIs
for depression?
, - answer-Tramadol (concurrent use of SSRI with tramadol can cause
serotonin syndrome)
On fundoscopic examination, which condition is associated with cherry red
spots of the macula?
- answer-Retinal artery occlusion
Which disease is associated with decreased uroporphyringoen
decarboxylase activity?
- answer-Porphyria cutanea tarda
Best next step after pt has tried NSAIDs / OCPs for primary dymenorrhea
but symptoms persist >3 months?
- answer-Ultrasound to rule out uterine abnormalities like fibroids
What is the anti-depressant category of choice in patients with bulemia?
- answer-SSRIs
What is the main anti-depressant to be avoided in patients with seizure
disorder?
- answer-Buproprion
Anaphlyaxis reaction is an example of which type of hypersensitivity
reaction?
- answer-Type 1 hypersensitivity reaction
Which class of anti-depressants are associated with widened QRS complex
that can be treated with bicarbonate?
- answer-Tricyclic antidepressants (TCAs)
Which statin is the drug of choice in HIV patients?
- answer-Pravastatin
Within what age range does USPSTF recommend one-time screening for
AAA in men with a smoking history?
- answer-65 to 75 years
Name the supplement: Sleep aid also used for stress/anxiety relief. If
combined with EtOH, can oversedate.
- answer-Kava
