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INTERNAL MEDICINE EXAM ANSWER KEY 2026: Complete Study Guide with Definitions, Etiology, Symptoms & Diagnosis

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Ace Your Internal Medicine Exam with This Comprehensive Answer Key & Study Guide for 2026! Stop guessing and start understanding with this complete answer key and study guide covering the entire internal medicine curriculum. This document is a comprehensive reference that provides detailed information on all major diseases, including definitions, etiology, pathogenesis, symptoms, physical examination findings, lab tests, and complications—all in an easy-to-navigate format. This isn't just a list of answers; it's a complete learning resource designed to help you understand the "why" behind the diagnosis and treatment. I have compiled detailed explanations for over 40 major internal medicine topics. Inside, you will master the "must-know" diseases, including: Pulmonology (10+ Topics): Acute tracheobronchitis, COPD, pulmonary emphysema, bronchiectasis, bronchial asthma, lobar pneumonia, bronchopneumonia, interstitial pneumonia, pulmonary embolism, lung cancer, pleurisy, and pulmonary tuberculosis. Cardiology (15+ Topics): Heart failure, cardiac shock, acute/subacute endocarditis, myocarditis, cardiomyopathies, pericarditis, rheumatism, mitral insufficiency, mitral stenosis, aortic insufficiency, aortic stenosis, arterial hypertension, stable/unstable angina, and myocardial infarction. Nephrology (6+ Topics): Acute renal failure, chronic renal failure, acute glomerulonephritis, chronic glomerulonephritis, nephrolithiasis, renal colic, and tubulointerstitial nephritis. Gastroenterology (15+ Topics): GERD, acute/chronic gastritis, gastric/duodenal ulcer, gastric cancer, acute/chronic enteritis, gluten enteropathy, ulcerative colitis, colon/rectal cancer, IBS, acute/chronic hepatitis, liver cirrhosis (portal hypertension, ascites, encephalopathy), primary hepatic cancer, cholelithiasis, jaundice, cholecystitis, acute/chronic pancreatitis, and pancreatic cancer. Hematology (7+ Topics): Iron deficiency anemia, B12/folate deficiency anemia, acute leukemia, chronic myeloid leukemia, chronic lymphoid leukemia, multiple myeloma, and essential thrombocytopenia. Endocrinology (6+ Topics): Hyperthyroidism (Graves' disease), hypothyroidism (Hashimoto's), hypocorticism (Addison's disease), hypercorticism (Cushing's syndrome), diabetes mellitus, and gout. Rheumatology (3+ Topics): Rheumatoid arthritis, ankylosing spondylitis, and degenerative arthropathy (osteoarthritis). This document is your ultimate review tool for the Internal Medicine Exam 2026. Whether you are a medical student, a resident preparing for the ITE, or a physician studying for board certification, this comprehensive answer key and study guide will deepen your understanding and boost your confidence. Everything is 100% verified and guaranteed to help you pass.

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28)Acute thracheobronchitis and bronchitis
Definition: inflammation of the bronchi.
Ethyiology; virus or bacterial infection, air pollution
Symptoms:Cough (obligatory) dry in the beginning, later with sputum;
Fever, weakness, fatigue, loss of appetite;
Retrosternal pain during cough as a sign of tracheitis.
Shortness of breath in bronchiolitis
Physical examination
Intoxicated face if the patient is with fever;
Coarse or decreased vesicular breathing with snoring wheezes and ronchi.
Whistling wheezes in spastic bronchitis.
Lab test:
Occasionally increased WBC(3.5-5.5) and sedimentation rate(in men 5-15;
in women 8-20)
Microbiology
Sputum culture for bacterial infection
Serological test for viral infections
Radiology
Increased lung markings
Spirometry
Restrictive type respiratory failure in bronchiolitis
Blood gases hypoxemia often with hypercapnia
Complications
Pneumonia
Chronic bronchitis
acute thrachea bronchitis
definition :is an common inflammation afflicting the lower respiratory
tract,composed of tracheitis and bronchitis.
etiology:virus ,bacteria infection,chemical and physical irratants
symptoms:
dry cough(obligatory)later with sputum (sometime with blood)
fever
weakness
fatigue
shortness of breath
ronchi
phsycal examinaton:
-intoxicated face if the patient is with fever
-coarse or decreased vesicular breathing with snoring wheezes and ronchi
lab test:
occasionally increased WBC(3.5-10.5)
sedimentation rate (in men 5-15—in women 8-20)
microbiology:
-sputum culture for bacterial infection
-serological test for viral infection
radiology:
incread lung margines
spirometry:
restrictive type respiratory failure in bronchiolitis(decreased)
blood gases hypoxemia often with hypercapnia

,Complications:
pneumonia ,chronic bronchitis.

29)Chronic Obstructive Pulmonary Diesease
Definition: cough three months in a row, during two consecutive years
Predisposition factors
Frequent respiratory infections, especially bronchitis and sinusitis, smoking,
polluted
environment, cold
Symptoms
Occasionally slight morning cough, during exacerbation same as acute
bronchitis
phsycal examinaton:
-intoxicated face if the patient is with fever
-coarse or decreased vesicular breathing with snoring wheezes and ronchi
lab test:
occasionally increased WBC(3.5-10.5)
sedimentation rate (in men 5-15—in women 8-20)
microbiology:
-sputum culture for bacterial infection
-serological test for viral infection
radiology:
incread lung margines
spirometry:
restrictive type respiratory failure in bronchiolitis(decreased)
blood gases hypoxemia often with hypercapnia
Complications
Bronchiaectases
Pulmonary emphysema
Pneumofibrosis
Pulmonary emphysema
Definition – anatomical condition of the lungs with constant enlargement
of the airspaces
distally from the terminal bronchioli and destruction of the alveoli
membranes.
Ethyology, pathogenesis and predisposition factors
Main pathogenic factor is bronchial obstruction in few cases congenital
factor –
deficiency of alpha-1-antitrypsin.
Pulmonary emphysema is a complication of chronic bronchitis,
bronchiectasis, and bronchial asthma
Symptoms: shortness of breath, initially during exercise, later at rest, but it
is not relieved significantly in sitting position.
Easy tiredness, fatigue, often cough with sputum.
Physical examination
In patient with respiratory failure general cyanosis and polycythaemia
Short neck, sometimes high neck veins
Emphysema type chest
Decreased vocal fremitus, box-like percussion sound, lower position of
lung bases,

,reduced respiratory mobility, decreased vesicular breathing with
prolonged exhale, often
whistling and snoring wheezes.
Lab tests
Increased HB(120-180), RBC(3,5-5,5), HTC(35-55) and low sedimentation
rate(in men 5-15—inwomen 8-20) in patients with respiratory failure and
polycytaemia.
Radiography
More air in the lung, dilated intercostal spaces, often increased lung
markings for
concomitant chronic bronchitis and bronchiectasis.
Spirometry - restrictive type respiratory failure.
Blood gazes – hypoxemia and hypercapnia, decreased oxygen
saturation.
Complications
Right heart failure very rare pneumothorax.
Pulmonary emphysema, chronic bronchitis and bronchiectasis
Bronchiectases
Definition: local dilatation of the bronchi
Predisposition factors
Chronic bronchitis, pneumonia, congenital (cystic fibrosis)
Symptoms
Cough with much sputum, especially in the morning and breath odor.
The sputum is
in three levels – upper foam-like, middle – mucous, lower – purulent,
occasionally
haemoptysis (blood in the sputum)
During exacerbation the same as in acute bronchitis, but more severe,
nearer to
pneumonia
Physical examination
Mainly in auscultation - decreased vesicular breathing with ronchi, which
are resonant,
when there is inflammation of the parenchyma
Occasionally clubbing of the fingers
Lab tests
Increased WBC(3,5-5,5) and sedimentation rate(in men 5-15-in women
8-20)
Microbiology
Sputum culture
Radiology
Increased lung markings, stretching to the periphery of the lung
CAT - cylindrical or sack-like dilatations of the bronchi.
Spirometry
Occasionally restrictive type respiratory failure
Blood gases hypoxemia, sometimes with hypercapnia
Complications
Acute- Local: pneumonia, pulmonary abscesses
General: myocarditis, pericarditis, endocarditis, encephalitis, meningitis,
sepsis;

, Chronic- Local: pneumofibrosis, pulmonary emphysema
General: amyloidosis
30) Bronchiectases
Definition: local dilatation of the bronchi
Predisposition factors
Chronic bronchitis, pneumonia, congenital (cystic fibrosis)
Symptoms
Cough with much sputum, especially in the morning and breath odor.
The sputum is
in three levels – upper foam-like, middle – mucous, lower – purulent,
occasionally
haemoptysis (blood in the sputum)
During exacerbation the same as in acute bronchitis, but more severe,
nearer to
pneumonia
Physical examination
Mainly in auscultation - decreased vesicular breathing with ronchi, which
are resonant,
when there is inflammation of the parenchyma
Occasionally clubbing of the fingers
Lab tests
Increased WBC(3,5-5,5) and sedimentation rate(in men 5-15-in women 8-
20)
Microbiology
Sputum culture
Radiology
Increased lung markings, stretching to the periphery of the lung
CAT - cylindrical or sack-like dilatations of the bronchi.
Spirometry
Occasionally restrictive type respiratory failure
Blood gases hypoxemia, sometimes with hypercapnia
Complications
Acute-
Local: pneumonia, pulmonary abscesses
General: myocarditis, pericarditis, endocarditis, encephalitis, meningitis,
sepsis;
Chronic-
Local: pneumofibrosis, pulmonary emphysema
General: amyloidosis

31)Bronchial Asthma
Definition: in most cases allergic disease causing attacks of
breathlessness while exhaling
Classification: atopic and nonatopic
Ethyology and predisposition factors:
For the atopic asthma: family predisposition with increased levels of IgE
For the non-atopic type: infections - mainly pneumonia or sinusitis in
childhood
Special types of asthma:

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