NR 565 Midterm
Terms in this set (58)
,G-Protien coupled receptors and how G-protein coupled receptors (GPCR) interact with
they interact with drugs drugs through 7 regions of proteins that span and
innervate the cell membrane and trap the molecule
into the receptor site like an interwoven basket (Insel &
Sriram, 2018). Drugs can then enter this space and
interact with the GRCP. A specific interaction and
binding with a site on one or more of the regions of
proteins within the GPCR, and drugs bound with the
GRCP can stimulate the release of G proteins that can
interact with various effector proteins to create
physiological responses within the body (Insel &
Sriram, 2018). This process occurs through secondary
messengers (such as cAMP) which creates the
extracellular interactions produced by the drug
binding to the GRCP.
,What neurotransmitters are excitatory? amino acids such as glycine, aspartate, and glutamate
are excitatory (Woo & Robinson, p.16, 2016).
Which is the most common CYP According to the textbook, the CYP3A4 is the most
enzyme in the body? What role does it important enzyme in the body. CYP3A4 is responsible
play? for the metabolism of more than 50% of medications
and is considered a major drug metabolizing enzyme.
CYP3A4 can be found in the liver, as well as the lining
of the GI tract. Due to this location, food can also
influence this CYP. One example of this is grapefruit
juice, which can inhibit CYP3A4. Medications that are
metabolized by CYP3A4 include antimicrobials,
calcium channel blockers, antihistamines,
anticonvulsants, azole antifungals, and corticosteroids
(Woo, & Robinson, 2016).
, What is the clinical significance of People who are ultra-rapid metabolizers have high
being an ultra-rapid CYP2D6 activity of CYP2D6 enzymes that break down certain
metabolizer? medicines rapidly and are likely to need different doses
or even a different medicine. Drug dose, response, and
toxicity risk of beta-blockers, antidepressants,
antiarrhythmics, and opioid analgesics are dependent
on CYP2D6 pharmacogenetics (Ayazseven et al.,
2020). Knowing the result of the CYP2D6 test and
which group the patient falls into such as poor
metabolizers, intermediate metabolizers, or ultra-rapid
metabolizers, will help nurse practitioners prescribe
the right medication and dosage for the patient.
Terms in this set (58)
,G-Protien coupled receptors and how G-protein coupled receptors (GPCR) interact with
they interact with drugs drugs through 7 regions of proteins that span and
innervate the cell membrane and trap the molecule
into the receptor site like an interwoven basket (Insel &
Sriram, 2018). Drugs can then enter this space and
interact with the GRCP. A specific interaction and
binding with a site on one or more of the regions of
proteins within the GPCR, and drugs bound with the
GRCP can stimulate the release of G proteins that can
interact with various effector proteins to create
physiological responses within the body (Insel &
Sriram, 2018). This process occurs through secondary
messengers (such as cAMP) which creates the
extracellular interactions produced by the drug
binding to the GRCP.
,What neurotransmitters are excitatory? amino acids such as glycine, aspartate, and glutamate
are excitatory (Woo & Robinson, p.16, 2016).
Which is the most common CYP According to the textbook, the CYP3A4 is the most
enzyme in the body? What role does it important enzyme in the body. CYP3A4 is responsible
play? for the metabolism of more than 50% of medications
and is considered a major drug metabolizing enzyme.
CYP3A4 can be found in the liver, as well as the lining
of the GI tract. Due to this location, food can also
influence this CYP. One example of this is grapefruit
juice, which can inhibit CYP3A4. Medications that are
metabolized by CYP3A4 include antimicrobials,
calcium channel blockers, antihistamines,
anticonvulsants, azole antifungals, and corticosteroids
(Woo, & Robinson, 2016).
, What is the clinical significance of People who are ultra-rapid metabolizers have high
being an ultra-rapid CYP2D6 activity of CYP2D6 enzymes that break down certain
metabolizer? medicines rapidly and are likely to need different doses
or even a different medicine. Drug dose, response, and
toxicity risk of beta-blockers, antidepressants,
antiarrhythmics, and opioid analgesics are dependent
on CYP2D6 pharmacogenetics (Ayazseven et al.,
2020). Knowing the result of the CYP2D6 test and
which group the patient falls into such as poor
metabolizers, intermediate metabolizers, or ultra-rapid
metabolizers, will help nurse practitioners prescribe
the right medication and dosage for the patient.
