MMSC 433 Exam Three Questions &
Answers (Grade A+)
What is the chromosomal abnormality for CML? -
correct answer ✅BCR/ABL1
What is the chromosomal abnormality for PV(Polycythemia Vera)? -
correct answer ✅JAK2
Myeloproliferative neoplasms are... -
correct answer ✅Clonal hematopoietic disorders caused by
mutations in hematopoietic cells, results in expansion, excessive
production, accumulation of erythrocytes, granulocytes and
platelets
What do Myeloproliferative neoplasms include? -
correct answer ✅CML,PV, ET and PMF
What is CML (chronic myeloid leukemia)? -
correct answer ✅1 translocation in a pluripotential HSC producing
a clonal overproduction of the myeloid cell line.
What is CML most associated with? -
correct answer ✅Chromosome t(9;22)
,MMSC 433 Exam Three Questions &
Answers (Grade A+)
What are the symptoms of CML? -
correct answer ✅Anemia, bleeding, splenomegaly. Often
transitions to AML
What is the treatment of CML? -
correct answer ✅Gleevec first line therapy
What is CML have absence of? -
correct answer ✅Ph1, BCR/ABL
What is the hallmark of CML? -
correct answer ✅Philadelphia chromosome
What is the Philadelphia chromosome? -
correct answer ✅Chromsome 9;22
Normal ABL gene -
correct answer ✅Kinase (adds phosphate groups), involved in cell
growth and proliferation
,MMSC 433 Exam Three Questions &
Answers (Grade A+)
What is normal BCR gene? -
correct answer ✅GTPase activating protein (GAP), cell signaling,
active when bound to GTP
BCR/ABL1 fusion gene -
correct answer ✅Identified with Philadelphia chromosome-
positive ALL
Gleevec Resistance -
correct answer ✅Primary unable to reach remission milestones.
Accounts for most tx failures. Point mutation at ATP binding
site(>60 defined). Secondary, loss of previous response
CML accelerated phase -
correct answer ✅Poor response to treatment, 20%+ basophils in
PB, 10-19% blasts in the PB and/or BM, ↑ splenomegaly
What is the additional clonal chromosomal abnormalities? -
correct answer ✅Second Ph 8+,19+
Blastic phase -
correct answer ✅Blasts make up >20% of total BM cellularity.
, MMSC 433 Exam Three Questions &
Answers (Grade A+)
Extramedullary growth may occur as lymphocytic or myelogenous
cell proliferations. Severe anemia, thrombocytopenia, and
Leukopenia of all WBCs except blasts.
Chromosomal abnormalities -
correct answer ✅Additional Ph, trisomy 8, loss of Y chromosome,
trisomy 19
Diagnosis of CML -
correct answer ✅nRBCs, ↑WBCs, ↓leukocyte alkaline
phosphatase. ↑ BM cellularity (myeloblast, promyelocyte,
metamyelocytes, bands, and segs)
Leukocyte alkaline phosphatase (LAP) stain -
correct answer ✅LAP hydrolyzes substrate liberating naphthol to
make the granules pink.
What is the Lap score in CML -
correct answer ✅Decreased
Diagnosis Criteria for CML, BCR-ABL-1 in PB smear -
correct answer ✅↑ neutrophils and precursors (promyelocytes,
Answers (Grade A+)
What is the chromosomal abnormality for CML? -
correct answer ✅BCR/ABL1
What is the chromosomal abnormality for PV(Polycythemia Vera)? -
correct answer ✅JAK2
Myeloproliferative neoplasms are... -
correct answer ✅Clonal hematopoietic disorders caused by
mutations in hematopoietic cells, results in expansion, excessive
production, accumulation of erythrocytes, granulocytes and
platelets
What do Myeloproliferative neoplasms include? -
correct answer ✅CML,PV, ET and PMF
What is CML (chronic myeloid leukemia)? -
correct answer ✅1 translocation in a pluripotential HSC producing
a clonal overproduction of the myeloid cell line.
What is CML most associated with? -
correct answer ✅Chromosome t(9;22)
,MMSC 433 Exam Three Questions &
Answers (Grade A+)
What are the symptoms of CML? -
correct answer ✅Anemia, bleeding, splenomegaly. Often
transitions to AML
What is the treatment of CML? -
correct answer ✅Gleevec first line therapy
What is CML have absence of? -
correct answer ✅Ph1, BCR/ABL
What is the hallmark of CML? -
correct answer ✅Philadelphia chromosome
What is the Philadelphia chromosome? -
correct answer ✅Chromsome 9;22
Normal ABL gene -
correct answer ✅Kinase (adds phosphate groups), involved in cell
growth and proliferation
,MMSC 433 Exam Three Questions &
Answers (Grade A+)
What is normal BCR gene? -
correct answer ✅GTPase activating protein (GAP), cell signaling,
active when bound to GTP
BCR/ABL1 fusion gene -
correct answer ✅Identified with Philadelphia chromosome-
positive ALL
Gleevec Resistance -
correct answer ✅Primary unable to reach remission milestones.
Accounts for most tx failures. Point mutation at ATP binding
site(>60 defined). Secondary, loss of previous response
CML accelerated phase -
correct answer ✅Poor response to treatment, 20%+ basophils in
PB, 10-19% blasts in the PB and/or BM, ↑ splenomegaly
What is the additional clonal chromosomal abnormalities? -
correct answer ✅Second Ph 8+,19+
Blastic phase -
correct answer ✅Blasts make up >20% of total BM cellularity.
, MMSC 433 Exam Three Questions &
Answers (Grade A+)
Extramedullary growth may occur as lymphocytic or myelogenous
cell proliferations. Severe anemia, thrombocytopenia, and
Leukopenia of all WBCs except blasts.
Chromosomal abnormalities -
correct answer ✅Additional Ph, trisomy 8, loss of Y chromosome,
trisomy 19
Diagnosis of CML -
correct answer ✅nRBCs, ↑WBCs, ↓leukocyte alkaline
phosphatase. ↑ BM cellularity (myeloblast, promyelocyte,
metamyelocytes, bands, and segs)
Leukocyte alkaline phosphatase (LAP) stain -
correct answer ✅LAP hydrolyzes substrate liberating naphthol to
make the granules pink.
What is the Lap score in CML -
correct answer ✅Decreased
Diagnosis Criteria for CML, BCR-ABL-1 in PB smear -
correct answer ✅↑ neutrophils and precursors (promyelocytes,
