MMSC 433 Exam 3 Questions &
Answers (Grade A+)
chronic myeloid leukemia (CML) chromosomal abnormality -
correct answer ✅Philadelphia chromosome (~95% of cases)
polycythemia vera (PV) chromosomal abnormality -
correct answer ✅JAK2V617F mutation (most cases)
chronic myeloproliferative disorders -
correct answer ✅-chronic myeloid leukemia (CML)
-polycythemia vera (PV)
-essential thrombocythemia (ET)
-primary myelofibrosis (PMF)
-chronic neutrophilic leukemia (CNL)
-chronic myelomonocytic leukemia (CMML)
-juvenile myelomonocytic leukemia (JMML)
polycythemia vera major criteria (WHO) -
correct answer ✅-hemoglobin >16.5 g/dL (men), >16 g/dL
(women)
-Hct >49% (men), >48% (women)
-increased RCM >35 mL/kg (men), >31 mL/kg (women)
-BM biopsy with hypercellularity and panmyelosis
,MMSC 433 Exam 3 Questions &
Answers (Grade A+)
-presence of JAK2V617F or JAK2 Exon 12 mutations
polycythemia vera minor criteria (WHO) -
correct answer ✅subnormal serum EPO levels
chronic myeloid leukemia (CML) -
correct answer ✅-etiology: a single genetic translocation in a
pluripotent hematopoietic stem cell causes clonal overproduction
of immature neutrophils, usually diagnosed between age 45-55
-chromosomal abnormality: Philadelphia chromosome
-morphology: myeloblasts, promyelovytes, bands, segmented
neutrophils (all stages of neutrophil development) seen in the
peripheral blood, nRBCs present, *gaucher-like macrophages
present*, very small megakaryocytes present
-symptoms: infections with Strep pneumoniae, anemia, bleeding,
splenomegaly
-PB: RBCs normal to inc, retics normal, total WBCs increased,
granulocytes increased (neutrophils, basophils, eosinophils), PLTs
normal to inc, *LAP stain decreased*
-BM: hypercellular, increased granulopoiesis, decreased
erythropoiesis, megakaryopoiesis increased, reticulin fibers
increased
, MMSC 433 Exam 3 Questions &
Answers (Grade A+)
chronic myeloid leukemia (CML) stages -
correct answer ✅chronic phase (3-4 years) → accelerated phase →
blastic phase → possible transition to acute leukemia (poor
prognosis)
chronic myeloid leukemia (CML) treatments -
correct answer ✅-BM transplant or SCT= CURE
-*gleevec* (imatnib mesylate)
-sprycel, dasigna, bosulib, iclusig
polycythemia vera (PV) -
correct answer ✅-etiology: neoplastic clonal stem cells mature
independently of EPO stimulation, causing panmyelosis with a
predominate increase in erythrocytes (grans and PLTs can be
increased too)
-Chromosomal abnormality: JAK2V617F mutation
-morphology: N/N RBCs, teardrop cells (dacrocytes) present
-symptoms: triad of BM fibrosis, splenomegaly and anemia w/
teardrop cells (dacrocytes)
-lab findings: Hgb/ Hct/ RCM increased, low serum EPO levels
Answers (Grade A+)
chronic myeloid leukemia (CML) chromosomal abnormality -
correct answer ✅Philadelphia chromosome (~95% of cases)
polycythemia vera (PV) chromosomal abnormality -
correct answer ✅JAK2V617F mutation (most cases)
chronic myeloproliferative disorders -
correct answer ✅-chronic myeloid leukemia (CML)
-polycythemia vera (PV)
-essential thrombocythemia (ET)
-primary myelofibrosis (PMF)
-chronic neutrophilic leukemia (CNL)
-chronic myelomonocytic leukemia (CMML)
-juvenile myelomonocytic leukemia (JMML)
polycythemia vera major criteria (WHO) -
correct answer ✅-hemoglobin >16.5 g/dL (men), >16 g/dL
(women)
-Hct >49% (men), >48% (women)
-increased RCM >35 mL/kg (men), >31 mL/kg (women)
-BM biopsy with hypercellularity and panmyelosis
,MMSC 433 Exam 3 Questions &
Answers (Grade A+)
-presence of JAK2V617F or JAK2 Exon 12 mutations
polycythemia vera minor criteria (WHO) -
correct answer ✅subnormal serum EPO levels
chronic myeloid leukemia (CML) -
correct answer ✅-etiology: a single genetic translocation in a
pluripotent hematopoietic stem cell causes clonal overproduction
of immature neutrophils, usually diagnosed between age 45-55
-chromosomal abnormality: Philadelphia chromosome
-morphology: myeloblasts, promyelovytes, bands, segmented
neutrophils (all stages of neutrophil development) seen in the
peripheral blood, nRBCs present, *gaucher-like macrophages
present*, very small megakaryocytes present
-symptoms: infections with Strep pneumoniae, anemia, bleeding,
splenomegaly
-PB: RBCs normal to inc, retics normal, total WBCs increased,
granulocytes increased (neutrophils, basophils, eosinophils), PLTs
normal to inc, *LAP stain decreased*
-BM: hypercellular, increased granulopoiesis, decreased
erythropoiesis, megakaryopoiesis increased, reticulin fibers
increased
, MMSC 433 Exam 3 Questions &
Answers (Grade A+)
chronic myeloid leukemia (CML) stages -
correct answer ✅chronic phase (3-4 years) → accelerated phase →
blastic phase → possible transition to acute leukemia (poor
prognosis)
chronic myeloid leukemia (CML) treatments -
correct answer ✅-BM transplant or SCT= CURE
-*gleevec* (imatnib mesylate)
-sprycel, dasigna, bosulib, iclusig
polycythemia vera (PV) -
correct answer ✅-etiology: neoplastic clonal stem cells mature
independently of EPO stimulation, causing panmyelosis with a
predominate increase in erythrocytes (grans and PLTs can be
increased too)
-Chromosomal abnormality: JAK2V617F mutation
-morphology: N/N RBCs, teardrop cells (dacrocytes) present
-symptoms: triad of BM fibrosis, splenomegaly and anemia w/
teardrop cells (dacrocytes)
-lab findings: Hgb/ Hct/ RCM increased, low serum EPO levels
