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MMSC 433 Exam Questions And Answers Latest U

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MMSC 433 Exam Questions And
Answers Latest Update
Define Hemoglobinopathy -
correct answer ✅-a disease state (opathy) involving the
hemoglobin molecule
-Result from a genetic mutation in one or more genes that affect
hgb
-Qualitative or quantitative


List the etiology of qualitative hemoglobinopathies. -
correct answer ✅-Hgb molecule has an altered amino acid
sequence within globulin chain (beta very common)
-Alters hgb molecule because placement of amino acids is crucial to
hgb functionality


State the amino acid substitution associated with sickle cell disease
-
correct answer ✅-𝜶2β2^ (6Glu-Val)
-Change valine in place of glutamic acid in 6 position causes sickled
red blood cells


-Glutamic acid= Net charge of -1, Polar

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