MMSC 433 Exam 2 Questions &
Answers (Grade A+)
In sickle cell anemia what amino acid replaces glutamic acid in the
sixth position of the beta chain -
correct answer ✅valine
Name the 3 clinical phases of sickle cell anemia -
correct answer ✅Aplastic
Hemolytic
VOC (vaso-occlusive crisis)
Besides sickle cells what other abnormal red cell morphology can
be seen in the peripheral blood smear of a SCA patient -
correct answer ✅target cells
Name a clinical manifestation of sickle cell anemia -
correct answer ✅autosplenectomy
leg ulcers
acute chest syndrome
avascular necrosis
classify the anemia in sickle cell anemia -
correct answer ✅normocytic/normochromic
,MMSC 433 Exam 2 Questions &
Answers (Grade A+)
qualitative hemoglobinopathies are when -
correct answer ✅hemoglobin has altered amino acid sequence
within globin chain
is sickle cell qualitative or quantitative -
correct answer ✅qualitative
is thalasemia quantitative or qualtiative -
correct answer ✅quantitative
Quantitative hemoglobinopathies occur when -
correct answer ✅reduced rate of globin production
Sickle cell anemia genotype -
correct answer ✅ss
Sickle cell trait genotype -
correct answer ✅as
, MMSC 433 Exam 2 Questions &
Answers (Grade A+)
Hgb C disease genotype -
correct answer ✅cc
Hgb C trait genotype -
correct answer ✅Ac
Hgb C-Harlem mutations -
correct answer ✅glutamic acid to valine on 6
asparagine to aspartic acid on 73
What does Hgb C-Harlem migrate with on acetate -
correct answer ✅Hgb C
What does Hgb-C harlem migrate with on citrate -
correct answer ✅Hgb S
Hgb SC genotype -
correct answer ✅SC
Sickle cell disease mutation -
correct answer ✅glutamic acid to valine on 6th beta chain
Answers (Grade A+)
In sickle cell anemia what amino acid replaces glutamic acid in the
sixth position of the beta chain -
correct answer ✅valine
Name the 3 clinical phases of sickle cell anemia -
correct answer ✅Aplastic
Hemolytic
VOC (vaso-occlusive crisis)
Besides sickle cells what other abnormal red cell morphology can
be seen in the peripheral blood smear of a SCA patient -
correct answer ✅target cells
Name a clinical manifestation of sickle cell anemia -
correct answer ✅autosplenectomy
leg ulcers
acute chest syndrome
avascular necrosis
classify the anemia in sickle cell anemia -
correct answer ✅normocytic/normochromic
,MMSC 433 Exam 2 Questions &
Answers (Grade A+)
qualitative hemoglobinopathies are when -
correct answer ✅hemoglobin has altered amino acid sequence
within globin chain
is sickle cell qualitative or quantitative -
correct answer ✅qualitative
is thalasemia quantitative or qualtiative -
correct answer ✅quantitative
Quantitative hemoglobinopathies occur when -
correct answer ✅reduced rate of globin production
Sickle cell anemia genotype -
correct answer ✅ss
Sickle cell trait genotype -
correct answer ✅as
, MMSC 433 Exam 2 Questions &
Answers (Grade A+)
Hgb C disease genotype -
correct answer ✅cc
Hgb C trait genotype -
correct answer ✅Ac
Hgb C-Harlem mutations -
correct answer ✅glutamic acid to valine on 6
asparagine to aspartic acid on 73
What does Hgb C-Harlem migrate with on acetate -
correct answer ✅Hgb C
What does Hgb-C harlem migrate with on citrate -
correct answer ✅Hgb S
Hgb SC genotype -
correct answer ✅SC
Sickle cell disease mutation -
correct answer ✅glutamic acid to valine on 6th beta chain
