MMSC433 Exam 3 Objectives Exam
Questions & Answers (Grade A+)
Myeloproliferative disorders -
correct answer ✅CML → Chronic Myeloid Leukemia
PV → Polycythemia Vera
ET → Essential Thrombocythemia
PMF → Primary Myelofibrosis
Others:
-Chronic Neutrophilic Leukemia
-Chronic Myelomonocytic Leukemia
-Juvenile Myelomonocytic Leukemia
CML -
correct answer ✅Single genetic translocation in pluripotential
hematopoietic stem cell producing a clonal overproduction of the
myeloid cell line, resulting in a preponderance of increased
immature cells in the neutrophilic line
-chronic phase can turn into accelerated phase in 3-4 yrs if
untreated
-can transition to AML or ALL
,MMSC433 Exam 3 Objectives Exam
Questions & Answers (Grade A+)
CML clinical features -
correct answer ✅Anemia
Bleeding
Splenomegaly
Infections w strep pneumoniae
CML chromosomal abnormality -
correct answer ✅Philadelphia chromosome
Philadelphia chromosome -
correct answer ✅translocation of chromosome 9 to BCR of band
q11 of chromosome 22
Normal ABL (abselson) gene -
correct answer ✅functions as kinase (adds phosphate)
normal BCR gene -
correct answer ✅functions as GTPase activating protein (GAP)
-active when bound to GTP
,MMSC433 Exam 3 Objectives Exam
Questions & Answers (Grade A+)
BCR-ABL1 fusion gene -
correct answer ✅identified w/ philadelphia chromosome (positive
ALL)
CML morphology/lab findings -
correct answer ✅-RBC ↓
-LAP ↓
-Reticulocytes normal
-lymphocytes/PLTs normal
-WBC, neutrophil, basophil, eosinophil, myelocyte ↑
-Gaucher-like cells (sea blue)
-Green-gray crystal ↑
-All extramedullary tissue present
CML Treatment -
correct answer ✅-BM + stem cell transplant (CURE)
-Imatinib mesylate (Gleevec) → treatment of choice
Goal of CML therapy -
correct answer ✅absence of Ph1, BCR/ABL
, MMSC433 Exam 3 Objectives Exam
Questions & Answers (Grade A+)
State WHO criteria for the accelerated phase of CML -
correct answer ✅-PB leukocytosis due to increased number of
neutrophils and their precursors
-Dysgranulopoiesis - may include abnormal chromatin clumping
-No or minimal absolute basophilia; basophils usually <2% of
leukocytes
-No or menial absolute monocytosis; monocytes <10% of
leukocytes
-Hypercellular BM with granulocytic proliferation and granulocytic
dysplasia, with or without dysplasia in the erythroid and
megakaryocytic lineages
-<20% blasts in the blood and BM
-No evidence of PDGFRA, PDGFRB, or FGFR1 rearrangement, or
PCM1-JAK2
-Not meeting WHO criteria for BCR-ABL+ CML, PMF, PV, or ET
PV -
correct answer ✅Neoplastic clonal myeloproliferative disorder
that commonly manifests with panmyelosis in the BM and increases
in erythrocytes, granulocytes, and PLTs in the PB
-Neoplastic clonal stem cells function independently of EPO for cell
growth
Questions & Answers (Grade A+)
Myeloproliferative disorders -
correct answer ✅CML → Chronic Myeloid Leukemia
PV → Polycythemia Vera
ET → Essential Thrombocythemia
PMF → Primary Myelofibrosis
Others:
-Chronic Neutrophilic Leukemia
-Chronic Myelomonocytic Leukemia
-Juvenile Myelomonocytic Leukemia
CML -
correct answer ✅Single genetic translocation in pluripotential
hematopoietic stem cell producing a clonal overproduction of the
myeloid cell line, resulting in a preponderance of increased
immature cells in the neutrophilic line
-chronic phase can turn into accelerated phase in 3-4 yrs if
untreated
-can transition to AML or ALL
,MMSC433 Exam 3 Objectives Exam
Questions & Answers (Grade A+)
CML clinical features -
correct answer ✅Anemia
Bleeding
Splenomegaly
Infections w strep pneumoniae
CML chromosomal abnormality -
correct answer ✅Philadelphia chromosome
Philadelphia chromosome -
correct answer ✅translocation of chromosome 9 to BCR of band
q11 of chromosome 22
Normal ABL (abselson) gene -
correct answer ✅functions as kinase (adds phosphate)
normal BCR gene -
correct answer ✅functions as GTPase activating protein (GAP)
-active when bound to GTP
,MMSC433 Exam 3 Objectives Exam
Questions & Answers (Grade A+)
BCR-ABL1 fusion gene -
correct answer ✅identified w/ philadelphia chromosome (positive
ALL)
CML morphology/lab findings -
correct answer ✅-RBC ↓
-LAP ↓
-Reticulocytes normal
-lymphocytes/PLTs normal
-WBC, neutrophil, basophil, eosinophil, myelocyte ↑
-Gaucher-like cells (sea blue)
-Green-gray crystal ↑
-All extramedullary tissue present
CML Treatment -
correct answer ✅-BM + stem cell transplant (CURE)
-Imatinib mesylate (Gleevec) → treatment of choice
Goal of CML therapy -
correct answer ✅absence of Ph1, BCR/ABL
, MMSC433 Exam 3 Objectives Exam
Questions & Answers (Grade A+)
State WHO criteria for the accelerated phase of CML -
correct answer ✅-PB leukocytosis due to increased number of
neutrophils and their precursors
-Dysgranulopoiesis - may include abnormal chromatin clumping
-No or minimal absolute basophilia; basophils usually <2% of
leukocytes
-No or menial absolute monocytosis; monocytes <10% of
leukocytes
-Hypercellular BM with granulocytic proliferation and granulocytic
dysplasia, with or without dysplasia in the erythroid and
megakaryocytic lineages
-<20% blasts in the blood and BM
-No evidence of PDGFRA, PDGFRB, or FGFR1 rearrangement, or
PCM1-JAK2
-Not meeting WHO criteria for BCR-ABL+ CML, PMF, PV, or ET
PV -
correct answer ✅Neoplastic clonal myeloproliferative disorder
that commonly manifests with panmyelosis in the BM and increases
in erythrocytes, granulocytes, and PLTs in the PB
-Neoplastic clonal stem cells function independently of EPO for cell
growth
