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Orphan Annie Eye Nuclei in Papillary Carcinoma of The Thyroid Gland

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Orphan Annie Eye Nuclei in Papillary Carcinoma of The Thyroid Gland

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MD Doctor
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MD Doctor

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Comics in Medicine_The Orphan Annie
June 21, 2020




Note the vacant eyes


A famous 1900's daily American comic strip, Little
Orphan Annie illustrated its lead character as a girl with
red hair, red dress, and vacant circles for eyes.

Papillary Carcinoma of the thyroid gland(PCT) is
characterised by 2 distinct features on light microscopy,
namely Orphan Annie eye nuclei and Psammoma bodies.

In PCT,the cells of the thyroid gland i.e., the thyrocytes
are large and show an abnormal nucleus and cytoplasm
with several mitoses.

The thyrocytes have characteristic "Orphan Annie eye
nuclei" as explained in the figure below.
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Uploaded on
July 3, 2021
Number of pages
3
Written in
2020/2021
Type
Judgments

Subjects

  • carcinoma
  • papillary
  • thyroid
  • orphan
  • annie
  • eye
  • comic
  • vacant
  • nucleus
  • chromatin
  • orphan annie eye nuclei in papillary carcinoma of the thyroid gland
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