NRNP 6566 WK1-5 Midterm
Study online at https://quizlet.com/_jtmm2j
1. Describe cy- Cytochrome p450 system is a series of enzymes used to metabolize medications
tochrome p450
system
2. Inhibitors block metabolic activity from one or more CYP450 enzymes
3. Inducers increase CYP450 enzyme activity by increasing enzyme synthesis
4. Describe effect Albumin is the plasma protein with the greatest capacity for binding drugs. Binding
on low and high plasma proteins affect drug distribution into tissues, because only drug that is not
albumin levels bound is available to penetrate tissues, bind to receptors, and exert activity. As free
on active drug drug leaves the blood stream, more bound drug is released from binding sites.
levels especially
for drugs that
are highly protein
bound
5. Low albumin lev- malnutrition, chronic illness
els
6. Highly protein toxicity in patients with low albumin levels, example malnutrition or chronic illness.
bound drugs can This is because there are fewer than the normal sites for the drug to bind
lead to
7. Describe the Alternative routes include:
ways the hepatic suppository
first pass effect- intravenous
which is metabo- intramuscular
lism during first inhalational aerosol
pass through the transdermal
liver sublingual
1/8
, NRNP 6566 WK1-5 Midterm
Study online at https://quizlet.com/_jtmm2j
These allow drugs to bypass the first-pass effect and be absorbed directly into
systemic circulation
8. Be able to cal- Male = 140-age times weight in kilograms divided by serum creatinine times 72.
culate creatinine Women = CRCL (male) times 0.85
clearance using
Cockgraft Gault
equation:
9. Describe what half life
determines the plasma concentration
frequency of
drug administra-
tion
10. Be familiar with Potentially Inappropriate Medication Use in Older Adults
the beers criteria to call attention to medications that are most commonly problematic and thus
and how to use it should be avoided in older adults
11. Describe factors low blood state (shock or arrest), contact time with GI tract too fast (diarrhea =
that affect ab- cant absorb), delayed stomach emptying (large meal = delayed absorption)Drug-
sorption to drug or drug to food interactions
12. Describe the fac- low albumin levels, body composition, cardiac decompensation (heart failure), age
tors that affect
distribution
13. Describe the fac- genetics, age, organ function
tors that affect
metabolism
14. affected by abnormal kidney or liver function, age, drug interactions
2/8
Study online at https://quizlet.com/_jtmm2j
1. Describe cy- Cytochrome p450 system is a series of enzymes used to metabolize medications
tochrome p450
system
2. Inhibitors block metabolic activity from one or more CYP450 enzymes
3. Inducers increase CYP450 enzyme activity by increasing enzyme synthesis
4. Describe effect Albumin is the plasma protein with the greatest capacity for binding drugs. Binding
on low and high plasma proteins affect drug distribution into tissues, because only drug that is not
albumin levels bound is available to penetrate tissues, bind to receptors, and exert activity. As free
on active drug drug leaves the blood stream, more bound drug is released from binding sites.
levels especially
for drugs that
are highly protein
bound
5. Low albumin lev- malnutrition, chronic illness
els
6. Highly protein toxicity in patients with low albumin levels, example malnutrition or chronic illness.
bound drugs can This is because there are fewer than the normal sites for the drug to bind
lead to
7. Describe the Alternative routes include:
ways the hepatic suppository
first pass effect- intravenous
which is metabo- intramuscular
lism during first inhalational aerosol
pass through the transdermal
liver sublingual
1/8
, NRNP 6566 WK1-5 Midterm
Study online at https://quizlet.com/_jtmm2j
These allow drugs to bypass the first-pass effect and be absorbed directly into
systemic circulation
8. Be able to cal- Male = 140-age times weight in kilograms divided by serum creatinine times 72.
culate creatinine Women = CRCL (male) times 0.85
clearance using
Cockgraft Gault
equation:
9. Describe what half life
determines the plasma concentration
frequency of
drug administra-
tion
10. Be familiar with Potentially Inappropriate Medication Use in Older Adults
the beers criteria to call attention to medications that are most commonly problematic and thus
and how to use it should be avoided in older adults
11. Describe factors low blood state (shock or arrest), contact time with GI tract too fast (diarrhea =
that affect ab- cant absorb), delayed stomach emptying (large meal = delayed absorption)Drug-
sorption to drug or drug to food interactions
12. Describe the fac- low albumin levels, body composition, cardiac decompensation (heart failure), age
tors that affect
distribution
13. Describe the fac- genetics, age, organ function
tors that affect
metabolism
14. affected by abnormal kidney or liver function, age, drug interactions
2/8
