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350 Nursing Exam Questions: Medical-Surgical Nursing

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This comprehensive practice exam bank is your ultimate study resource for medical-surgical nursing exams, including the NCLEX-RN. With 350 multiple-choice questions, detailed answers, and clear rationales, this guide covers the full spectrum of medical-surgical nursing knowledge required for success in nursing school and on certification exams. What's Inside This Complete Study Guide? This practice exam is organized into three key sections that mirror the content of medical-surgical nursing curricula and the NCLEX: Questions 1-75: Fundamentals of Medical-Surgical Nursing: Build a solid foundation in essential med-surg concepts. Topics include heart failure management (furosemide, digoxin), COPD and oxygen therapy, acute pancreatitis, DVT assessment, tracheostomy care, blood transfusion reactions, warfarin monitoring (INR), cirrhosis and portal hypertension, myocardial infarction care, appendicitis, and pulmonary embolism diagnosis. Questions 76-200: Cardiovascular, Respiratory, Renal, Endocrine, and Gastrointestinal Nursing: Dive deep into the most common conditions in these critical body systems. This comprehensive section covers hypertensive crisis, amiodarone side effects, heart failure with reduced ejection fraction (HFrEF), peripheral artery disease, atrial fibrillation, mitral stenosis, chest tube management, diabetic ketoacidosis (DKA), hyperthyroidism, chronic kidney disease (CKD), liver cirrhosis, ascites, acute pancreatitis, and urinary tract infections. Questions 201-275: Neurological, Musculoskeletal, and Integumentary Nursing: Master the care of patients with neurological and musculoskeletal conditions. Topics include Glasgow Coma Scale (GCS) assessment, spinal cord injury complications (autonomic dysreflexia, DVT, pressure ulcers), stroke care (dysphagia, aphasia, fall prevention), Parkinson's disease (levodopa/carbidopa), seizure disorders (phenytoin, valproic acid, carbamazepine), pressure ulcer staging, compartment syndrome, and head injury management (increased ICP). Questions 276-350: Pharmacology, Emergency, and Critical Care Nursing: Build a strong foundation in medication administration and emergency nursing. This section covers amiodarone (pulmonary fibrosis, thyroid dysfunction), metronidazole (alcohol interaction), vancomycin (red man syndrome, nephrotoxicity), ACE inhibitors (hyperkalemia), beta-blockers (bradycardia, bronchospasm), opioids (constipation, respiratory depression), statins (myopathy), insulin therapy, corticosteroids (hyperglycemia), and proton pump inhibitors (vitamin B12 deficiency). Why Choose This Guide? Realistic Practice: Get the most authentic test-taking experience with 350 questions designed to reflect the actual difficulty and style of nursing exams and the NCLEX. Detailed Rationales: Every question includes a clear, concise rationale that explains why the answer is correct and why the other options are not. This is crucial for building deep understanding, not just memorization. Updated for 2026: Stay current with the latest evidence-based practice and guidelines. Comprehensive Coverage: One resource covers the entire scope of medical-surgical nursing—no need to search through multiple books or websites. Pass Your Exam with Confidence: This guide is designed to help you pass your nursing exam and advance your career with a solid foundation of knowledge.

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350 Nursing Exam Questions: Medical-Surgical
Nursing


Questions 1-75: Fundamentals of Medical-Surgical Nursing


Question 1
A patient with heart failure is prescribed furosemide. Which laboratory value
should the nurse monitor most closely?
A) Serum sodium
B) Serum potassium
C) Serum calcium
D) Serum magnesium


Correct Answer: B) Serum potassium


Rationale: Furosemide is a loop diuretic that causes significant potassium loss
through the kidneys. Hypokalemia can lead to cardiac arrhythmias, especially
in patients with heart failure who may also be taking digoxin. Serum
potassium should be monitored closely and maintained within normal range
(3.5-5.0 mEq/L).


---


Question 2
A patient is admitted with acute pancreatitis. Which position should the nurse
encourage to help reduce the patient's pain?

,A) Supine position
B) Prone position
C) Side-lying with knees flexed
D) High Fowler's position


Correct Answer: C) Side-lying with knees flexed


Rationale: The side-lying position with knees flexed (fetal position) helps
reduce abdominal tension and decreases pressure on the pancreas, which can
help alleviate pain. This position also promotes relaxation of the abdominal
muscles.


---


Question 3
A nurse is caring for a patient with a new tracheostomy. Which action is most
important when providing tracheostomy care?
A) Using sterile technique for inner cannula cleaning
B) Applying petroleum jelly around the stoma
C) Changing the tracheostomy ties daily
D) Keeping the patient flat in bed


Correct Answer: A) Using sterile technique for inner cannula cleaning


Rationale: Sterile technique must be maintained during tracheostomy care to
prevent infection. The inner cannula should be cleaned using sterile supplies.

,Petroleum jelly should not be used around the stoma as it can be aspirated.
Tracheostomy ties should be changed when soiled or at least weekly.


---


Question 4
A patient with chronic obstructive pulmonary disease (COPD) has an oxygen
saturation of 88%. Which oxygen delivery method is most appropriate?
A) Nasal cannula at 2 L/min
B) Simple face mask at 6 L/min
C) Non-rebreather mask at 10 L/min
D) Venturi mask at 24%


Correct Answer: D) Venturi mask at 24%


Rationale: For COPD patients, oxygen should be administered cautiously using
a Venturi mask, which delivers precise oxygen concentrations. The goal is to
maintain oxygen saturation between 88-92% to avoid suppressing the
hypoxic drive. A Venturi mask at 24% provides the most accurate and
controlled oxygen delivery.


---


Question 5
A patient is experiencing chest pain and is prescribed sublingual nitroglycerin.
The nurse administers one tablet, and the patient's pain persists after 5
minutes. What should the nurse do next?
A) Administer a second tablet immediately

, B) Call the healthcare provider
C) Wait 10 more minutes before administering another tablet
D) Administer a second tablet after 5 minutes if pain continues


Correct Answer: D) Administer a second tablet after 5 minutes if pain
continues


Rationale: Standard protocol for sublingual nitroglycerin is to administer one
tablet, and if pain persists after 5 minutes, administer a second tablet. Up to
three tablets can be given at 5-minute intervals. If pain continues after three
tablets, emergency medical services should be activated.


---


Question 6
A nurse is assessing a patient with suspected deep vein thrombosis (DVT).
Which finding is most indicative of DVT?
A) Bilateral lower extremity edema
B) Unilateral calf pain and swelling
C) Diminished pedal pulses bilaterally
D) Cool, pale extremities


Correct Answer: B) Unilateral calf pain and swelling


Rationale: Unilateral calf pain, swelling, warmth, and redness are classic signs
of DVT. Bilateral edema is more suggestive of heart failure or venous
insufficiency. Diminished pulses and cool extremities are more indicative of
arterial insufficiency.

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