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HESI Pharmacology Exam Questions & Answers PDF | NCLEX-PN Complete Practice Test | Latest 2026–2027

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Prepare for the HESI Pharmacology Exam and NCLEX-PN® with this comprehensive Questions & Answers PDF, designed for practical nursing students preparing for pharmacology assessments, HESI specialty exams, and NCLEX-PN review. The resource covers high-yield pharmacology topics including drug classifications, mechanisms of action, indications and contraindications, adverse effects, drug interactions, nursing implications, safe medication administration, dosage calculations, cardiovascular medications, antibiotics, endocrine medications, respiratory drugs, gastrointestinal medications, neurological and psychiatric medications, analgesics, anticoagulants, antihypertensives, insulin and oral antidiabetics, medication safety, patient education, monitoring parameters, and clinical-priority questions. Elsevier's current HESI Comprehensive Review for the NCLEX-PN, 8th Edition, published in 2026, specifically includes pharmacology tables highlighting essential drug-therapy content, clinical-judgment questions with rationales, and alternate-item practice formats.

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HESI Pharmacology Exam Practice 2026-2027 (NCLEX PN) 2 VERSIONS ACTUAL EXAM
2.) Oral iron supplements are prescribed for a 6-year- 4. Orange juice
old child with iron deficiency anemia. The nurse Rationale:
instructs the mother to administer the iron with which Vitamin C increases the absorption of iron by the body. The mother should be
best food item? instructed to administer the medication with a citrus fruit or a juice that is high in
1. Milk vitamin C. Milk may affect absorption of the iron. Water will not assist in
2. Water absorption. Orange juice contains a greater amount of vitamin C than apple
3. Apple juice juice.
4. Orange juice


3.) Salicylic acid is prescribed for a client with a 1. Tinnitus
diagnosis of psoriasis. The nurse monitors the client, Rationale:
knowing that which of the following would indicate the Salicylic acid is absorbed readily through the skin, and systemic toxicity
presence of systemic toxicity from this medication? (salicylism) can result. Symptoms include tinnitus, dizziness, hyperpnea, and
1. Tinnitus psychological disturbances. Constipation and diarrhea are not associated with
2. Diarrhea salicylism.
3. Constipation
4. Decreased respirations




4.) The camp nurse asks the children preparing to swim 4. At least 30 minutes before exposure to the sun
in the lake if they have applied sunscreen. The nurse Rationale:
reminds the children that chemical sunscreens are most Sunscreens are most effective when applied at least 30 minutes before
effective when applied: exposure to the sun so that they can penetrate the skin. All sunscreens should
1. Immediately before swimming be reapplied after swimming or sweating.
2. 15 minutes before exposure to the sun
3. Immediately before exposure to the sun
4. At least 30 minutes before exposure to the sun


5.) Mafenide acetate (Sulfamylon) is prescribed for the 3. Informing the client that this is normal
client with a burn injury. When applying the medication, Rationale:
the client complains of local discomfort and burning. Mafenide acetate is bacteriostatic for gram-negative and gram-positive
Which of the following is the most appropriate nursing organisms and is used to treat burns to reduce bacteria present in avascular
action? tissues. The client should be informed that the medication will cause local
1. Notifying the registered nurse discomfort and burning and that this is a normal reaction; therefore options 1, 2,
2. Discontinuing the medication and 4 are incorrect
3. Informing the client that this is normal
4. Applying a thinner film than prescribed to the burn
site


6.) The burn client is receiving treatments of topical 1.Hyperventilation
mafenide acetate (Sulfamylon) to the site of injury. The Rationale:
nurse monitors the client, knowing that which of the Mafenide acetate is a carbonic anhydrase inhibitor and can suppress renal
following indicates that a systemic effect has occurred? excretion of acid, thereby causing acidosis. Clients receiving this treatment
1.Hyperventilation should be monitored for signs of an acid-base imbalance (hyperventilation). If
2.Elevated blood pressure this occurs, the medication should be discontinued for 1 to 2 days. Options 3
3.Local pain at the burn site and 4 describe local rather than systemic effects. An elevated blood pressure
4.Local rash at the burn site may be expected from the pain that occurs with a burn injury.

,HESI Pharmacology Exam Practice 2026-2027 (NCLEX PN) 2 VERSIONS ACTUAL EXAM
7.) Isotretinoin is prescribed for a client with severe 2. Triglyceride level
acne. Before the administration of this medication, the Rationale:
nurse anticipates that which laboratory test will be Isotretinoin can elevate triglyceride levels. Blood triglyceride levels should be
prescribed? measured before treatment and periodically thereafter until the effect on the
1. Platelet count triglycerides has been evaluated. Options 1, 3, and 4 do not need to be
2. Triglyceride level monitored specifically during this treatment.
3. Complete blood count
4. White blood cell count


8.) A client with severe acne is seen in the clinic and the 1. Vitamin A
health care provider (HCP) prescribes isotretinoin. The Rationale:
nurse reviews the client's medication record and would Isotretinoin is a metabolite of vitamin A and can produce generalized
contact the (HCP) if the client is taking which intensification of isotretinoin toxicity. Because of the potential for increased
medication? toxicity, vitamin A supplements should be discontinued before isotretinoin
1. Vitamin A therapy. Options 2, 3, and 4 are not contraindicated with the use of isotretinoin.
2. Digoxin (Lanoxin)
3. Furosemide (Lasix)
4. Phenytoin (Dilantin)


9.) The nurse is applying a topical corticosteroid to a 2. Axilla
client with eczema. The nurse would monitor for the Rationale:
potential for increased systemic absorption of the Topical corticosteroids can be absorbed into the systemic circulation.
medication if the medication were being applied to Absorption is higher from regions where the skin is especially permeable
which of the following body areas? (scalp, axilla, face, eyelids, neck, perineum, genitalia), and lower from regions in
1. Back which permeability is poor (back, palms, soles).
2. Axilla
3. Soles of the feet
4. Palms of the hands


10.) The clinic nurse is performing an admission 1. Acne
assessment on a client. The nurse notes that the client is Rationale:
taking azelaic acid (Azelex). Because of the medication Azelaic acid is a topical medication used to treat mild to moderate acne. The
prescription, the nurse would suspect that the client is acid appears to work by suppressing the growth of Propionibacterium acnes
being treated for: and decreasing the proliferation of keratinocytes. Options 2, 3, and 4 are
1. Acne incorrect.
2. Eczema
3. Hair loss
4. Herpes simplex


11.) The health care provider has prescribed silver 3. "The medication will permanently stain my skin."
sulfadiazine (Silvadene) for the client with a partial- Rationale:
thickness burn, which has cultured positive for gram- Silver sulfadiazine (Silvadene) is an antibacterial that has a broad spectrum of
negative bacteria. The nurse is reinforcing information activity against gram-negative bacteria, gram-positive bacteria, and yeast. It is
to the client about the medication. Which statement applied directly to the wound to assist in healing. It does not stain the skin.
made by the client indicates a lack of understanding
about the treatments?
1. "The medication is an antibacterial."
2. "The medication will help heal the burn."
3. "The medication will permanently stain my skin."
4. "The medication should be applied directly to the
wound."

,HESI Pharmacology Exam Practice 2026-2027 (NCLEX PN) 2 VERSIONS ACTUAL EXAM
12.) A nurse is caring for a client who is receiving an 1. Notify the registered nurse.
intravenous (IV) infusion of an antineoplastic Rationale:
medication. During the infusion, the client complains of When antineoplastic medications (Chemotheraputic Agents) are administered
pain at the insertion site. During an inspection of the via IV, great care must be taken to prevent the medication from escaping into
site, the nurse notes redness and swelling and that the the tissues surrounding the injection site, because pain, tissue damage, and
rate of infusion of the medication has slowed. The nurse necrosis can result. The nurse monitors for signs of extravasation, such as
should take which appropriate action? redness or swelling at the insertion site and a decreased infusion rate. If
1. Notify the registered nurse. extravasation occurs, the registered nurse needs to be notified; he or she will
2. Administer pain medication to reduce the discomfort. then contact the health care provider.
3. Apply ice and maintain the infusion rate, as
prescribed.
4. Elevate the extremity of the IV site, and slow the
infusion.




13.) The client with squamous cell carcinoma of the 4. Pulmonary function studies
larynx is receiving bleomycin intravenously. The nurse Rationale:
caring for the client anticipates that which diagnostic Bleomycin is an antineoplastic medication (Chemotheraputic Agents) that can
study will be prescribed? cause interstitial pneumonitis, which can progress to pulmonary fibrosis.
1. Echocardiography Pulmonary function studies along with hematological, hepatic, and renal
2. Electrocardiography function tests need to be monitored. The nurse needs to monitor lung sounds
3. Cervical radiography for dyspnea and crackles, which indicate pulmonary toxicity. The medication
4. Pulmonary function studies needs to be discontinued immediately if pulmonary toxicity occurs. Options 1,
2, and 3 are unrelated to the specific use of this medication.


14.) The client with acute myelocytic leukemia is being 2. Uric acid level
treated with busulfan (Myleran). Which laboratory value Rationale:
would the nurse specifically monitor during treatment Busulfan (Myleran) can cause an increase in the uric acid level. Hyperuricemia
with this medication? can produce uric acid nephropathy, renal stones, and acute renal failure.
1. Clotting time Options 1, 3, and 4 are not specifically related to this medication.
2. Uric acid level
3. Potassium level
4. Blood glucose level


15.) The client with small cell lung cancer is being 4. Orthostatic hypotension
treated with etoposide (VePesid). The nurse who is Rationale:
assisting in caring for the client during its administration A side effect specific to etoposide is orthostatic hypotension. The client's
understands that which side effect is specifically blood pressure is monitored during the infusion. Hair loss occurs with nearly all
associated with this medication? the antineoplastic medications. Chest pain and pulmonary fibrosis are
1. Alopecia unrelated to this medication.
2. Chest pain
3. Pulmonary fibrosis
4. Orthostatic hypotension

,HESI Pharmacology Exam Practice 2026-2027 (NCLEX PN) 2 VERSIONS ACTUAL EXAM
16.) The clinic nurse is reviewing a teaching plan for the 3. Consult with health care providers (HCPs) before receiving immunizations
client receiving an antineoplastic medication. When Rationale:
implementing the plan, the nurse tells the client: Because antineoplastic medications lower the resistance of the body, clients
1. To take aspirin (acetylsalicylic acid) as needed for must be informed not to receive immunizations without a HCP's approval.
headache Clients also need to avoid contact with individuals who have recently received
2. Drink beverages containing alcohol in moderate a live virus vaccine. Clients need to avoid aspirin and aspirin-containing
amounts each evening products to minimize the risk of bleeding, and they need to avoid alcohol to
3. Consult with health care providers (HCPs) before minimize the risk of toxicity and side effects.
receiving immunizations
4. That it is not necessary to consult HCPs before
receiving a flu vaccine at the local health fair


17.) The client with ovarian cancer is being treated with 4. Numbness and tingling in the fingers and toes
vincristine (Oncovin). The nurse monitors the client, Rationale:
knowing that which of the following indicates a side A side effect specific to vincristine is peripheral neuropathy, which occurs in
effect specific to this medication? almost every client. Peripheral neuropathy can be manifested as numbness and
1. Diarrhea tingling in the fingers and toes. Depression of the Achilles tendon reflex may be
2. Hair loss the first clinical sign indicating peripheral neuropathy. Constipation rather than
3. Chest pain diarrhea is most likely to occur with this medication, although diarrhea may
4. Numbness and tingling in the fingers and toes occur occasionally. Hair loss occurs with nearly all the antineoplastic
medications. Chest pain is unrelated to this medication.


18.) The nurse is reviewing the history and physical 1. Pancreatitis
examination of a client who will be receiving Rationale:
asparaginase (Elspar), an antineoplastic agent. The Asparaginase (Elspar) is contraindicated if hypersensitivity exists, in
nurse consults with the registered nurse regarding the pancreatitis, or if the client has a history of pancreatitis. The medication impairs
administration of the medication if which of the pancreatic function and pancreatic function tests should be performed before
following is documented in the client's history? therapy begins and when a week or more has elapsed between administration
1. Pancreatitis of the doses. The client needs to be monitored for signs of pancreatitis, which
2. Diabetes mellitus include nausea, vomiting, and abdominal pain. The conditions noted in options
3. Myocardial infarction 2, 3, and 4 are not contraindicated with this medication.
4. Chronic obstructive pulmonary disease


19.) Tamoxifen is prescribed for the client with 4. Compete with estradiol for binding to estrogen in tissues containing high
metastatic breast carcinoma. The nurse understands concentrations of receptors.
that the primary action of this medication is to: Rationale:
1. Increase DNA and RNA synthesis. Tamoxifen is an antineoplastic medication that competes with estradiol for
2. Promote the biosynthesis of nucleic acids. binding to estrogen in tissues containing high concentrations of receptors.
3. Increase estrogen concentration and estrogen Tamoxifen is used to treat metastatic breast carcinoma in women and men.
response. Tamoxifen is also effective in delaying the recurrence of cancer following
4. Compete with estradiol for binding to estrogen in mastectomy. Tamoxifen reduces DNA synthesis and estrogen response.
tissues containing high concentrations of receptors.


20.) The client with metastatic breast cancer is receiving 2. Calcium level
tamoxifen. The nurse specifically monitors which Rationale:
laboratory value while the client is taking this Tamoxifen may increase calcium, cholesterol, and triglyceride levels. Before
medication? the initiation of therapy, a complete blood count, platelet count, and serum
1. Glucose level calcium levels should be assessed. These blood levels, along with cholesterol
2. Calcium level and triglyceride levels, should be monitored periodically during therapy. The
3. Potassium level nurse should assess for hypercalcemia while the client is taking this medication.
4. Prothrombin time Signs of hypercalcemia include increased urine volume, excessive thirst,
nausea, vomiting, constipation, hypotonicity of muscles, and deep bone and
flank pain.

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