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COMSAE FORM 107 ACTUAL EXAM QUESTIONS WITH COMPLETE SOLUTION GUIDE (A+ GRADED | 100% VERIFIED) | LATEST VERSION 2026–2027

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Ace your COMSAE Form 107 assessment with this comprehensive study guide featuring practice questions and verified answers designed to support effective COMLEX board exam preparation. This resource covers the high-yield medical sciences tested on COMLEX-USA Level 1, including anatomy, physiology, biochemistry, pathology, pharmacology, microbiology, immunology, behavioral science, osteopathic principles and practice (OPP/OMM), ethics, epidemiology, patient safety, and integrated clinical reasoning through board-style questions. Ideal for osteopathic medical students preparing for COMSAE self-assessments and COMLEX-USA Level 1, this organized study material helps reinforce foundational medical concepts, strengthen clinical reasoning and board-style test-taking skills, improve exam readiness, and maximize your chances of success on the 2026/2027 COMSAE Form 107 and COMLEX Level 1 examinations.

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COMSAE Form 107 Study Guide | Practice Questions and Answers | COMLEX Exam Prep
imipramine TCA


SE: Tri-Cs
convulsions
coma
cardiotox


antichol effects- confusion in elderly; (acute glaucoma and orthostatic
hypotension- block alpha1)


viscerosomatic visceral disease --> somatic finding


loratidine vs ranitidine loratidine: 2nd gen H1 blocker, doesnt cross BBB --> less sedating


ranitidine: H2 receptor antagonist (like cimetidine)


cells w RBCs inside entaemoba histolytica


which type of pneumothorax causes tracheal deviation tension
to the contra side?


intracerebral hemorrhage adjacent to a lesion that AVM arteriovenous malformation
contains a tangle of numerous tortuous vessels


cavernous hemangioma benign tumor of liver, A/W VHL


anti-HepB surface antibody is only present in what pop recovered or immunized


not in chronic or


proctalgia fugax levator ani syndrome




fasciculus is UMN or LMN lesion? LMN


ectopic gastric tissue meckels diverticulum


can also have ectopic pancreatic tissue


remnant of vitelline duct


antibodies in hashimotos attacks thyroid peroxidase or antithyroglobulin


enlarged non tender thyroid

,COMSAE Form 107 Study Guide | Practice Questions and Answers | COMLEX Exam Prep
2 factors that influence starling curve x axis- preload (EDV)
y axis- stroke volume or CO


treatment for fibromyalgia TCA, SNRIs anticonvulsants


what blocks NE reuptake? TCA or SNRIs


possible complication of pagets bone disease osteocarcoma


what does Hct tell you? ratio of volume of RBCs compared to total blood volume


probenecid inhibits reabsoprtion of uric acid in PCT
- also inhibits secretion of PCN
- can ppt uric acid calculi




2 causes of SCID ADA deficiency
(adenosine deaminase required for degradation of adenosim and
deoxyadenosine
- in ADA deficiency, high levels of dATP --> toxicity in lymphocytes --> SCID


hypoplastic thymus


lithiums effects on urination inhibits vasopression/ADH --> increased urinary frequency


infertility drug that can result in multiple fetuses clomiphene (clones- multiple babies)


antagonist at estrogen R in hypothalamus (thus inhibits normal negative
feedback)


upregulates LH and FSH release from pituitary --> ovulation


used to treat PCOS but can cause ovarian enlargement, multiple fetuses


AFP levels in down syndrome low


GI malformation A/W down syndrome Hirschprungs- congenital aganglionic megacolon


defective relaxation and peristalsis of rectum and distal sigmoid colon


failure to pass meconium, empty rectal vault, megacolon


myasthenia gravis associations thymoma, thymic hyperplasia


ptosis, diplopia, can affect chewing, swallowing, speaking, shoulders,
respiration

,COMSAE Form 107 Study Guide | Practice Questions and Answers | COMLEX Exam Prep
tx for tinea azoles


beta blockers for asthma none- even beta 1s can be nonselective at higher doses


what kind of teratogenic effects are seen w ACE/ARBs fetal renal agenesis




stones bones groans moans psych overtones high Ca or PTH


PTH is made by what cells? chief cells of parathyroid gland


PTH inhibits reabsorption of phosphate where? PO4- proximal tubule
increases calcium resorption where? ca- DCT


anterior innominate rotation means tight hip flexors or extensor- hamstrings
extensors?


thoracic CS E SaRa


most common cause of cellultis staph aureus, strep pyogenes


FPR- direct or indirect? active or passive? indirect- place them in position of diagnosis
passive


cant treat kid w tetracycline so what do you give? amoxicillin


which Heps are there currently vaccines for? A and B (and so by virtue, also D)




why does Hep D need Hep B? Hep D utilizes the HBV surface antigen as its envelope?


most common hepatitis A/W IVDA in the US hep c

, COMSAE Form 107 Study Guide | Practice Questions and Answers | COMLEX Exam Prep
roseola 4 day high fever
then rash on the trunk (spares face)


affects babies up to 2 years


HHV6- affects CD4 helper cells and kills them off


erythema infectiosum slapped cheek


parvovirus B19


nonspecific fever/prodrome then slapp cheek rash 5 days later, then rash
appears on arms and spreads to trunk/legs


rash can worsen w fever and sun exposure


TORCH infxn so baby in womb that is exposed can lead to hydrops fetalis


most common STD chlamydia


sxs similar to STI plus discharge


will have high neutrophil count


dimorphic- butterflies candida, histo, cocci, paracocci, blasto, sporothrix,


butterflies huge pair of cocc catching stamp


hip restricted in internal rotation innom outflare


dx?


immune complex in glomerular mesangium 2 days after berger
URI
PSGN is 2 wks post URI
berger or PSGN?


kidney ureter viscerosomatic innervation T10-11


college student w nonspecific symptoms myco PNA


nonproductive cough, sore throat
CXR- diffuse infiltrates


test for trichomonas nucleic acid amplification


painless enlarging tumor in left testis 75 yo diffuse large B cell lymphoma


most common in 70-80s


choriocarcinoma affecst what age group 15-35


yolk sac tumor affects what population infants and children 1-2 years

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