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Module 2.1 – Introduction to Mendelian
Genetics
Historical Origins of Genetics
Why Study Heredity?
Heredity is the study of how traits are passed from parents to offspring.
Understanding heredity helps explain:
Why offspring resemble their parents.
Why inherited diseases occur.
How desirable traits can be selected in plants and animals.
Applications of genetics include:
Medicine
Agriculture
Evolutionary biology
Charles Darwin and Gregor Mendel
Charles Darwin
Interested in how traits were inherited.
Collected many observations about inheritance.
Was unable to develop a complete explanation because inheritance patterns
were difficult to interpret.
,Gregor Mendel
Focused on a single organism—the garden pea.
Used controlled experiments to study inheritance.
Discovered predictable patterns of heredity.
Considered the Father of Genetics.
Early Importance of Genetics
Researchers recognized that understanding heredity could improve:
Human Health
Examples include inherited diseases such as:
Hemophilia
Xeroderma Pigmentosum (XP)
Agriculture
Understanding inheritance allowed breeders to improve:
Crops
Livestock
Other domesticated plants and animals
Human Genetics Examples
Hemophilia
An inherited genetic disorder.
The lecture uses the descendants of Queen Victoria to demonstrate
inheritance through families.
Xeroderma Pigmentosum (XP)
The lecture introduces XP using twins Thomas and Vincent Seris.
, Characteristics:
Rare inherited disorder.
Extreme sensitivity to ultraviolet (UV) light.
Greatly increased risk of skin cancer.
Individuals require extensive protection from sunlight.
The lecture uses XP to introduce questions about inherited genetic diseases.
Mendel's Pea Plant Experiments
Why Pea Plants?
Mendel chose garden peas because they:
Were commercially available.
Had easily observed traits.
Could be bred in controlled crosses.
Included true-breeding varieties.
True-Breeding Strains
A true-breeding strain consistently produces offspring with the same trait when
self-fertilized.
Mendel crossed true-breeding plants that differed in a single characteristic.
Example:
Purple flowers × White flowers
Mendel's Results
First Generation (F )
Cross:
Purple × White