Lehne's Pharmacology for Nursing
Care, 12th Edition Test Bank
Author:Jacqueline Burchum, Laura
Rosenthal All Chapters Covered(1-
112)|Complete Guide A+ Graded
Pharmacokinetics - answer- The study of drug movement throughout the body
A term derived from two Greek words
Pharmakon= drug or poison
Kinesis= Motion
Four basic pharmacokinetic processes - answer- Absorption
Distribution
Metabolism
And excretion
Absorption - answer- Defined as the movement of a drug from its site of administration
into the blood
Distribution - answer- Defined as drug movement from the blood to the interstitial space
of tissues from there into cells
Metabolism - answer- Biotransformation
Defined as enzymatically mediated alteration of drug structure
Excretion - answer- movement of drugs and their metabolites out of the body
Elimination - answer- The combination of metabolism and excretion
Chemophobes - answer- Students who fear chemistry
Cytoplasmic membrane - answer- The membrane that surrounds every cell
Phospholipids - answer- The membrane structure consisting of a double layer of
molecules
, Simply lipids that contain an atom of phosphate
Three important ways drugs Cross cell membranes - answer- 1-passage through
channels or pores
2-passage with the aid of transport system
3-Direct penetration of the membrane itself
Transport systems - answer- Carriers that move drugs from one side of the cell
membrane to the other
P-glycoprotein (PGP) - answer- Transmembrane proteins that transports a wide variety
of drugs out of the cell
Why is movement for drugs throughout the body dependent on penetrating
membranes? - answer- 1-most drugs are too large to pass through channels are pores
2-most drugs lack transport systems to help them cross all the membranes that
separate them from their site of action, metabolism, and excretion
lipid soluble (lipophilic) - answer- Liking to or dissolving in lipids
Polar molecules - answer- Polar molecules are molecules with uneven distribution of
electrical charge
No net charge
I.e. water
I.e. of a polar drug is an anabiotic
Ions - answer- Molecules that do bear a net electrical charge that is positive or negative
Other than really small ones, they can't cross membranes
Quarternary ammonium compounds - answer- Molecules that contain at least one atom
of nitrogen and carry a positive charge at all times
Acid - answer- Compound that can give up a hydrogen ion (proton)
Proton donor
Base - answer- Compound that can take a hydrogen ion
Proton acceptor
Care, 12th Edition Test Bank
Author:Jacqueline Burchum, Laura
Rosenthal All Chapters Covered(1-
112)|Complete Guide A+ Graded
Pharmacokinetics - answer- The study of drug movement throughout the body
A term derived from two Greek words
Pharmakon= drug or poison
Kinesis= Motion
Four basic pharmacokinetic processes - answer- Absorption
Distribution
Metabolism
And excretion
Absorption - answer- Defined as the movement of a drug from its site of administration
into the blood
Distribution - answer- Defined as drug movement from the blood to the interstitial space
of tissues from there into cells
Metabolism - answer- Biotransformation
Defined as enzymatically mediated alteration of drug structure
Excretion - answer- movement of drugs and their metabolites out of the body
Elimination - answer- The combination of metabolism and excretion
Chemophobes - answer- Students who fear chemistry
Cytoplasmic membrane - answer- The membrane that surrounds every cell
Phospholipids - answer- The membrane structure consisting of a double layer of
molecules
, Simply lipids that contain an atom of phosphate
Three important ways drugs Cross cell membranes - answer- 1-passage through
channels or pores
2-passage with the aid of transport system
3-Direct penetration of the membrane itself
Transport systems - answer- Carriers that move drugs from one side of the cell
membrane to the other
P-glycoprotein (PGP) - answer- Transmembrane proteins that transports a wide variety
of drugs out of the cell
Why is movement for drugs throughout the body dependent on penetrating
membranes? - answer- 1-most drugs are too large to pass through channels are pores
2-most drugs lack transport systems to help them cross all the membranes that
separate them from their site of action, metabolism, and excretion
lipid soluble (lipophilic) - answer- Liking to or dissolving in lipids
Polar molecules - answer- Polar molecules are molecules with uneven distribution of
electrical charge
No net charge
I.e. water
I.e. of a polar drug is an anabiotic
Ions - answer- Molecules that do bear a net electrical charge that is positive or negative
Other than really small ones, they can't cross membranes
Quarternary ammonium compounds - answer- Molecules that contain at least one atom
of nitrogen and carry a positive charge at all times
Acid - answer- Compound that can give up a hydrogen ion (proton)
Proton donor
Base - answer- Compound that can take a hydrogen ion
Proton acceptor
