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Oncology Certified Nurse (OCN) Exam – Complete Test Bank | 250+ NGN-Style Questions with Verified Answers & Detailed Rationales | ONCC 2026 Blueprint Aligned

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Ace the Oncology Certified Nurse (OCN®) examination with this definitive, all-encompassing preparation resource, meticulously designed to reflect the official Oncology Nursing Certification Corporation (ONCC) test blueprint and the rigorous standards of oncology nursing practice. This comprehensive guide provides a full-spectrum review of the specialized clinical knowledge, assessment skills, and professional competencies required for board certification, covering everything from cancer biology and epidemiology to treatment modalities, symptom management, oncologic emergencies, and the psychosocial dimensions of cancer care.

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Oncology Certified Nurse (OCN) Exam – Complete Test Bank




Questions 1–250
Domain 1: Care Continuum (Questions 1–50)


1. A patient is diagnosed with Hodgkin lymphoma. The nurse
understands that this malignancy is characterized by the presence
of which type of cells?
A) Reed-Sternberg cells
B) Auer rods
C) Lewy bodies
D) Negri bodies
Answer A: Reed-Sternberg cells

,Rationale: Reed-Sternberg cells are large, binucleated or
multinucleated lymphocytes with prominent nucleoli, often described
as "owl-eyed," and are the hallmark of Hodgkin lymphoma.




2. A patient with a BRCA1 gene mutation is at increased risk for
which malignancies?
A) Lung and colon cancer
B) Breast and ovarian cancer
C) Pancreatic and gastric cancer
D) Prostate and testicular cancer
Answer B: Breast and ovarian cancer
Rationale: BRCA1 and BRCA2 mutations are associated with
significantly increased risks for breast and ovarian cancers.




3. A nurse is providing education about cancer screening. According
to the American Cancer Society, which screening recommendation
is appropriate for a 55-year-old male with average risk?
A) Annual PSA screening beginning at age 50
B) Colorectal cancer screening beginning at age 45

,C) Annual chest X-ray for lung cancer
D) Routine digital rectal exam annually
Answer B: Colorectal cancer screening beginning at age 45
Rationale: The American Cancer Society recommends colorectal
cancer screening beginning at age 45 for individuals at average risk.




4. A patient receiving chemotherapy develops neutropenia. Which
intervention is most important to prevent infection?
A) Encourage fresh fruits and vegetables
B) Implement neutropenic precautions (hand hygiene, avoid crowds,
no fresh flowers)
C) Administer prophylactic antibiotics
D) Restrict visitors completely
Answer B: Implement neutropenic precautions
Rationale: Neutropenic precautions include strict hand hygiene,
avoiding crowds, avoiding fresh flowers and plants, and monitoring
for signs of infection.

, 5. A cancer survivor reports persistent fatigue 6 months after
completing treatment. Which intervention should the nurse
recommend?
A) Complete bed rest
B) Graduated exercise program and energy conservation strategies
C) High-dose vitamin supplements
D) Restrict all physical activity
Answer B: Graduated exercise program and energy conservation
strategies
Rationale: Graduated exercise and energy conservation are evidence-
based interventions for cancer-related fatigue.




6. A patient with advanced cancer is experiencing dyspnea. Which
non-pharmacologic intervention is most appropriate?
A) Encourage supine positioning
B) Position the patient in high Fowler's with a fan circulating air
C) Restrict fluids
D) Administer high-flow oxygen only
Answer B: Position the patient in high Fowler's with a fan circulating
air

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