ANCC Family Nurse Practitioner (FNP-BC)
Comprehensive QUESTION Bank | Latest Board
Exam Practice QUESTIONs & Verified Answers
(2026/2027)
QUESTION 1
A client is diagnosed with metaplasia in the bronchial epithelium. The
nurse recognizes that this cellular adaptation:
A. Is an irreversible process indicating imminent malignancy.
B. Represents the replacement of one mature cell type with another,
often in response to chronic irritation.
C. Results in a significant increase in the rate of DNA replication and cell
division.
D. Is the direct result of a lack of oxygen to the bronchial tissue.
Correct Answer: B. Represents the replacement of one mature cell type
with another, often in response to chronic irritation.
,Detailed Rationale: Metaplasia is a reversible cellular adaptation where
one adult cell type is replaced by another, usually better suited to
survive a stressor (e.g., columnar epithelium changing to squamous
epithelium in smokers).
QUESTION 2
A 45-year-old male presents with chronic gastroesophageal reflux
disease (GERD). Endoscopy reveals Barrett esophagus. The nurse
practitioner recognizes that Barrett esophagus is an example of which
cellular adaptation?
A. Atrophy
B. Hyperplasia
C. Metaplasia
D. Dysplasia
Correct Answer: C. Metaplasia
,Detailed Rationale: Barrett esophagus involves the replacement of
normal stratified squamous epithelium with columnar epithelium due
to chronic acid irritation.
QUESTION 3
Which of the following clinical findings is most characteristic of
trigeminal neuralgia (tic douloureux)?
A. Continuous, dull, aching facial pain lasting for several hours
B. Unilateral, brief, electric shock-like pains triggered by light touch
C. Bilateral facial numbness and progressive muscle weakness
D. Loss of corneal reflex accompanied by drooping of the eyelid
Correct Answer: B. Unilateral, brief, electric shock-like pains triggered by
light touch
Detailed Rationale: Trigeminal neuralgia is characterized by sudden,
severe, brief, stabbing pain along the distribution of the trigeminal
nerve, often triggered by innocuous stimuli.
, QUESTION 4
A 68-year-old female presents with a 3-month history of progressive
proximal muscle weakness in her shoulders and hips, along with a
heliotrope rash on her eyelids and Gottron papules on her knuckles.
Which diagnostic test is most specific for confirming this diagnosis?
A. Erythrocyte sedimentation rate (ESR)
B. Serum creatine kinase (CK)
C. Anti-Jo-1 antibodies
D. Rheumatoid factor
Correct Answer: C. Anti-Jo-1 antibodies
Detailed Rationale: Dermatomyositis is characterized by proximal
muscle weakness and characteristic skin rashes. Anti-Jo-1 antibodies are
highly specific for inflammatory myopathies.
Comprehensive QUESTION Bank | Latest Board
Exam Practice QUESTIONs & Verified Answers
(2026/2027)
QUESTION 1
A client is diagnosed with metaplasia in the bronchial epithelium. The
nurse recognizes that this cellular adaptation:
A. Is an irreversible process indicating imminent malignancy.
B. Represents the replacement of one mature cell type with another,
often in response to chronic irritation.
C. Results in a significant increase in the rate of DNA replication and cell
division.
D. Is the direct result of a lack of oxygen to the bronchial tissue.
Correct Answer: B. Represents the replacement of one mature cell type
with another, often in response to chronic irritation.
,Detailed Rationale: Metaplasia is a reversible cellular adaptation where
one adult cell type is replaced by another, usually better suited to
survive a stressor (e.g., columnar epithelium changing to squamous
epithelium in smokers).
QUESTION 2
A 45-year-old male presents with chronic gastroesophageal reflux
disease (GERD). Endoscopy reveals Barrett esophagus. The nurse
practitioner recognizes that Barrett esophagus is an example of which
cellular adaptation?
A. Atrophy
B. Hyperplasia
C. Metaplasia
D. Dysplasia
Correct Answer: C. Metaplasia
,Detailed Rationale: Barrett esophagus involves the replacement of
normal stratified squamous epithelium with columnar epithelium due
to chronic acid irritation.
QUESTION 3
Which of the following clinical findings is most characteristic of
trigeminal neuralgia (tic douloureux)?
A. Continuous, dull, aching facial pain lasting for several hours
B. Unilateral, brief, electric shock-like pains triggered by light touch
C. Bilateral facial numbness and progressive muscle weakness
D. Loss of corneal reflex accompanied by drooping of the eyelid
Correct Answer: B. Unilateral, brief, electric shock-like pains triggered by
light touch
Detailed Rationale: Trigeminal neuralgia is characterized by sudden,
severe, brief, stabbing pain along the distribution of the trigeminal
nerve, often triggered by innocuous stimuli.
, QUESTION 4
A 68-year-old female presents with a 3-month history of progressive
proximal muscle weakness in her shoulders and hips, along with a
heliotrope rash on her eyelids and Gottron papules on her knuckles.
Which diagnostic test is most specific for confirming this diagnosis?
A. Erythrocyte sedimentation rate (ESR)
B. Serum creatine kinase (CK)
C. Anti-Jo-1 antibodies
D. Rheumatoid factor
Correct Answer: C. Anti-Jo-1 antibodies
Detailed Rationale: Dermatomyositis is characterized by proximal
muscle weakness and characteristic skin rashes. Anti-Jo-1 antibodies are
highly specific for inflammatory myopathies.
