BME 350 Final Exam Study Guide
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
______ are microfluidic cell and tissue culture systems that
recapitulate key physiologies and functions of specific organs for
further biological and medical purposes -
correct answer ✅organs-on-a-chip
the relationship between ___ and ___ is important. (i.e.,
microengineering/nanoengineering [structure]; cell biology
[function]) -
correct answer ✅- form
- function
what devices were commonly made of polydimethylsiloxane
(PDMS) using soft lithography techniques? -
correct answer ✅microfluidic
cell culture studies enable us to ___ almost all types of cells and to
characterize and culture them in vitro -
correct answer ✅isolate
although ___ ___ ___, such as animal models, HELP US
UNDERSTAND MANY BIOLOGICAL PHENOMENA, they are usually
,BME 350 Final Exam Study Guide
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
too complicated for mechanistic studies -
correct answer ✅in vivo studies
we might find a metastatic region in the lung a few weeks after a
cancer cell injection, but a rat model cannot fully explain how
cancer cells migrate to the lung, how they escape from the
circulatory system, and how they invade into lung tissue -
correct answer ✅example of how in vivo systems are usually too
complicated for mechanistic studies (motivation for organ on a
chip)
in vitro culture environments allow us to control the ___ and ___ of
cells as well as apply well-defined stimuli -
correct answer ✅- types
- numbers
___ between in vitro and in vivo drug test results provide an
excellent illustration of this problem -
correct answer ✅discrepancies
,BME 350 Final Exam Study Guide
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
culture systems are still to ___ to mimic the complexity of in vivo
systems -
correct answer ✅simple
in ___ systems are too complicated (e.g., animal models), and in
___ systems (e.g., petri dishes) are too simple to study the details
of biological phenomena -
correct answer ✅- vivo
- vitro
therefore, well-defined, mechanistic studies of these processes
demand ___ ___ that bridge this divide -
correct answer ✅model systems
many kinds of organ on a chip devices have been developed
including blood vessels, lung, liver, and others
- these devices capably REPRODUCE SELECT FUNCTIONS OF
SPECIFIC ORGANS and have been applied to answer important
biological and medical questions -
correct answer ✅examples of organ on a chip devices
, BME 350 Final Exam Study Guide
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
1. physiologically reasonable and
2. spatiotemporally controllable microenvironments -
correct answer ✅two most well-recognized advantages of organ
on a chip devices are their ability to provide
together (the two advantages of organ on a chip), these benefits
make the organ on a chip concept a ___ ___ for biological studies -
correct answer ✅powerful tool
in particular, the first advantage of organ on a chip is greatly
favorable when applied as a ______ platform -
correct answer ✅drug-testing
conventional drug-testing techniques, such as in vitro culture and
animal tests, often do not provide environments that are ___
relevant to humans, whereas an organ on a chip can provide this -
correct answer ✅physiologically
the second advantage of organ on a chip is greatly useful when it is
applied to in situ mechanistic studies such as real-time ___ ___
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
______ are microfluidic cell and tissue culture systems that
recapitulate key physiologies and functions of specific organs for
further biological and medical purposes -
correct answer ✅organs-on-a-chip
the relationship between ___ and ___ is important. (i.e.,
microengineering/nanoengineering [structure]; cell biology
[function]) -
correct answer ✅- form
- function
what devices were commonly made of polydimethylsiloxane
(PDMS) using soft lithography techniques? -
correct answer ✅microfluidic
cell culture studies enable us to ___ almost all types of cells and to
characterize and culture them in vitro -
correct answer ✅isolate
although ___ ___ ___, such as animal models, HELP US
UNDERSTAND MANY BIOLOGICAL PHENOMENA, they are usually
,BME 350 Final Exam Study Guide
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
too complicated for mechanistic studies -
correct answer ✅in vivo studies
we might find a metastatic region in the lung a few weeks after a
cancer cell injection, but a rat model cannot fully explain how
cancer cells migrate to the lung, how they escape from the
circulatory system, and how they invade into lung tissue -
correct answer ✅example of how in vivo systems are usually too
complicated for mechanistic studies (motivation for organ on a
chip)
in vitro culture environments allow us to control the ___ and ___ of
cells as well as apply well-defined stimuli -
correct answer ✅- types
- numbers
___ between in vitro and in vivo drug test results provide an
excellent illustration of this problem -
correct answer ✅discrepancies
,BME 350 Final Exam Study Guide
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
culture systems are still to ___ to mimic the complexity of in vivo
systems -
correct answer ✅simple
in ___ systems are too complicated (e.g., animal models), and in
___ systems (e.g., petri dishes) are too simple to study the details
of biological phenomena -
correct answer ✅- vivo
- vitro
therefore, well-defined, mechanistic studies of these processes
demand ___ ___ that bridge this divide -
correct answer ✅model systems
many kinds of organ on a chip devices have been developed
including blood vessels, lung, liver, and others
- these devices capably REPRODUCE SELECT FUNCTIONS OF
SPECIFIC ORGANS and have been applied to answer important
biological and medical questions -
correct answer ✅examples of organ on a chip devices
, BME 350 Final Exam Study Guide
(Tissue Engineering - TE) Questions &
Answers (Grade A+)
1. physiologically reasonable and
2. spatiotemporally controllable microenvironments -
correct answer ✅two most well-recognized advantages of organ
on a chip devices are their ability to provide
together (the two advantages of organ on a chip), these benefits
make the organ on a chip concept a ___ ___ for biological studies -
correct answer ✅powerful tool
in particular, the first advantage of organ on a chip is greatly
favorable when applied as a ______ platform -
correct answer ✅drug-testing
conventional drug-testing techniques, such as in vitro culture and
animal tests, often do not provide environments that are ___
relevant to humans, whereas an organ on a chip can provide this -
correct answer ✅physiologically
the second advantage of organ on a chip is greatly useful when it is
applied to in situ mechanistic studies such as real-time ___ ___
