COMSAE Phase 1 Form 114 Test Bank |
200+ Practice Questions with Bold Italic
Answers & Rationales – NBOME
Osteopathic Medical Knowledge Self-
Assessment Prep
"I passed my COMSAE Phase 1 Form 114 on the first attempt! The bold
italic answers made it easy to review, and the rationales helped me
understand the concepts, not just memorize answers. This was essential
for my COMLEX-USA Level 1 prep."
EXAM OVERVIEW
The COMSAE (Comprehensive Osteopathic Medical Self-
Assessment Examination) Phase 1 Form 114 is a practice examination
designed to assess readiness for the COMLEX-USA Level 1. This
guide provides comprehensive practice questions aligned with the
NBOME blueprint.
,Component Details
Exam Name COMSAE Phase 1 Form 114
Format Computer-Based, Multiple Choice
Questions Approximately 200–250 items
Time Limit 4 hours 30 minutes (approximately 4 blocks)
Osteopathic Principles & Practice, Anatomy, Biochemistry,
Content
Microbiology, Pathology, Pharmacology, Physiology, Behavioral
Areas Science, Clinical Presentation
Purpose Self-assessment for COMLEX-USA Level 1 readiness.
TABLE OF CONTENTS
Section Topic Questions
1 Osteopathic Principles & Practice (OPP) 1–20
2 Anatomy & Embryology 21–40
3 Biochemistry & Genetics 41–55
4 Microbiology & Immunology 56–75
5 Pathology 76–100
,Section Topic Questions
6 Pharmacology 101–120
7 Physiology 121–140
8 Behavioral Science & Ethics 141–155
9 Clinical Presentation & Diagnosis 156–180
10 Clinical Decision-Making & Management 181–200
SECTION 1: OSTEOPATHIC PRINCIPLES & PRACTICE (OPP)
1. A 45-year-old male presents with chronic low back pain. On
examination, you find restricted motion of the L5 vertebral segment on
flexion and extension. The patient reports that the pain worsens with
prolonged sitting. Which of the following somatic dysfunctions is most
consistent with these findings?
A) Type I somatic dysfunction
B) Type II somatic dysfunction
C) Fryette's Type I mechanics
D) Neutral mechanics
Rationale: Fryette's Type II mechanics occur when the spine is in a
non-neutral position (flexion or extension), with dysfunction in a
single vertebral segment. Type II dysfunctions are characterized by a
single vertebral segment that is restricted in the opposite direction of
side bending and rotation. The description of L5 restricted on flexion
and extension suggests a non-neutral dysfunction.
, 2. A patient presents with a diagnosis of acute bronchitis. The physician
performs lymphatic pump techniques to enhance immune function.
Which of the following best describes the physiological mechanism of
the lymphatic pump?
• A) Increases lymphatic flow and enhances immune
surveillance
• B) Decreases lymphatic flow to reduce inflammation
• C) Directly stimulates antibody production
• D) Increases sympathetic tone to fight infection
Rationale: The lymphatic pump (thoracic or pedal) increases lymphatic
flow through mechanical compression and release, enhancing lymphatic
circulation and immune surveillance. This technique is used in
osteopathic manipulative medicine (OMM) to support the immune
system, particularly in patients with respiratory infections.
3. A patient presents with a diagnosis of tension headache. On
examination, you find restricted motion of the occipitoatlantal (OA)
joint. The patient reports pain with rotation and side bending. Which of
the following is the correct diagnosis for this somatic dysfunction?
• A) OA flexion dysfunction
• B) OA extension dysfunction
• C) OA rotation dysfunction
• D) OA side bending dysfunction
Rationale: The occipitoatlantal joint is a modified condyloid joint that
allows for flexion, extension, and side bending. Rotation at the OA joint
is minimal; most rotation occurs at C1–C2. However, OA dysfunction
200+ Practice Questions with Bold Italic
Answers & Rationales – NBOME
Osteopathic Medical Knowledge Self-
Assessment Prep
"I passed my COMSAE Phase 1 Form 114 on the first attempt! The bold
italic answers made it easy to review, and the rationales helped me
understand the concepts, not just memorize answers. This was essential
for my COMLEX-USA Level 1 prep."
EXAM OVERVIEW
The COMSAE (Comprehensive Osteopathic Medical Self-
Assessment Examination) Phase 1 Form 114 is a practice examination
designed to assess readiness for the COMLEX-USA Level 1. This
guide provides comprehensive practice questions aligned with the
NBOME blueprint.
,Component Details
Exam Name COMSAE Phase 1 Form 114
Format Computer-Based, Multiple Choice
Questions Approximately 200–250 items
Time Limit 4 hours 30 minutes (approximately 4 blocks)
Osteopathic Principles & Practice, Anatomy, Biochemistry,
Content
Microbiology, Pathology, Pharmacology, Physiology, Behavioral
Areas Science, Clinical Presentation
Purpose Self-assessment for COMLEX-USA Level 1 readiness.
TABLE OF CONTENTS
Section Topic Questions
1 Osteopathic Principles & Practice (OPP) 1–20
2 Anatomy & Embryology 21–40
3 Biochemistry & Genetics 41–55
4 Microbiology & Immunology 56–75
5 Pathology 76–100
,Section Topic Questions
6 Pharmacology 101–120
7 Physiology 121–140
8 Behavioral Science & Ethics 141–155
9 Clinical Presentation & Diagnosis 156–180
10 Clinical Decision-Making & Management 181–200
SECTION 1: OSTEOPATHIC PRINCIPLES & PRACTICE (OPP)
1. A 45-year-old male presents with chronic low back pain. On
examination, you find restricted motion of the L5 vertebral segment on
flexion and extension. The patient reports that the pain worsens with
prolonged sitting. Which of the following somatic dysfunctions is most
consistent with these findings?
A) Type I somatic dysfunction
B) Type II somatic dysfunction
C) Fryette's Type I mechanics
D) Neutral mechanics
Rationale: Fryette's Type II mechanics occur when the spine is in a
non-neutral position (flexion or extension), with dysfunction in a
single vertebral segment. Type II dysfunctions are characterized by a
single vertebral segment that is restricted in the opposite direction of
side bending and rotation. The description of L5 restricted on flexion
and extension suggests a non-neutral dysfunction.
, 2. A patient presents with a diagnosis of acute bronchitis. The physician
performs lymphatic pump techniques to enhance immune function.
Which of the following best describes the physiological mechanism of
the lymphatic pump?
• A) Increases lymphatic flow and enhances immune
surveillance
• B) Decreases lymphatic flow to reduce inflammation
• C) Directly stimulates antibody production
• D) Increases sympathetic tone to fight infection
Rationale: The lymphatic pump (thoracic or pedal) increases lymphatic
flow through mechanical compression and release, enhancing lymphatic
circulation and immune surveillance. This technique is used in
osteopathic manipulative medicine (OMM) to support the immune
system, particularly in patients with respiratory infections.
3. A patient presents with a diagnosis of tension headache. On
examination, you find restricted motion of the occipitoatlantal (OA)
joint. The patient reports pain with rotation and side bending. Which of
the following is the correct diagnosis for this somatic dysfunction?
• A) OA flexion dysfunction
• B) OA extension dysfunction
• C) OA rotation dysfunction
• D) OA side bending dysfunction
Rationale: The occipitoatlantal joint is a modified condyloid joint that
allows for flexion, extension, and side bending. Rotation at the OA joint
is minimal; most rotation occurs at C1–C2. However, OA dysfunction
