NBME BIOCHEMISTRY SHELF EXAM 2026 FINAL
PAPER SOLVED QUESTIONS ANSWER KEY
APLUS
◉ What is a metabolite if epinephrine that suggests epi-secreting
carcinoma? What is another assoc symptom?
Answer: metanephrine; assoc with HBP
◉ What does acetazolamide (carbonic anhydrase ib) treat?
Answer: glaucoma, epilepsy, altitude sickness, congestive heart
failure
can cause dehydration
◉ Sickle cell anemia is due to...
Answer: pt mutation of Glu -> val
◉ What is a major neurotransmitter amino acid?
Answer: Glu
◉ HA protein of influenza binds to
Answer: cytokine receptors
,◉ What is a reducing-sugar test?
Answer: Tests for aldo-keto sugars
◉ What is omeprazole?
Answer: proton pump ib
◉ Name some GAG's.
Answer: heparin sulfate, chondroitin sulfate,
◉ What type of reaction is glucuronidation?
Answer: oxidation
◉ In Marfan's syndrome, what part of fibrillin's protein structure is
affected?
Answer: primary structure
◉ What are the symptoms of Huntington's disease?
Answer: anxiety, uncontrollable mvmts, slurring of speech, difficulty
focusing or concentrating; caused by triple repeat expansion
◉ What is Chediak-Higashi syndrome?
, Answer: phagocyte deficiency -> hypergammaglobulinemia,
significant neutropenia,
◉ In exposure to carbon monoxide or cyanide, which way does the
ox sat curve shift?
Answer: to the L; increased affinity at low pO_2
◉ What is pralidoxime chloride?
Answer: reactivate acetylcholinesterase
◉ Wernicke encephalopathy
Answer: inadequate thiamine; confusion, ophthalmoplagia
(nystagmus)
◉ What is the function of lactase?
Answer: beta(1->4) galactosidase; cleaves Gal from Glu
◉ How is fructose absorbed?
Answer: via sodium-independent transporter
◉ What sugar enzymes are found on the intestinal brush border?
Answer: sucrase, lactase, maltase, isomaltase
PAPER SOLVED QUESTIONS ANSWER KEY
APLUS
◉ What is a metabolite if epinephrine that suggests epi-secreting
carcinoma? What is another assoc symptom?
Answer: metanephrine; assoc with HBP
◉ What does acetazolamide (carbonic anhydrase ib) treat?
Answer: glaucoma, epilepsy, altitude sickness, congestive heart
failure
can cause dehydration
◉ Sickle cell anemia is due to...
Answer: pt mutation of Glu -> val
◉ What is a major neurotransmitter amino acid?
Answer: Glu
◉ HA protein of influenza binds to
Answer: cytokine receptors
,◉ What is a reducing-sugar test?
Answer: Tests for aldo-keto sugars
◉ What is omeprazole?
Answer: proton pump ib
◉ Name some GAG's.
Answer: heparin sulfate, chondroitin sulfate,
◉ What type of reaction is glucuronidation?
Answer: oxidation
◉ In Marfan's syndrome, what part of fibrillin's protein structure is
affected?
Answer: primary structure
◉ What are the symptoms of Huntington's disease?
Answer: anxiety, uncontrollable mvmts, slurring of speech, difficulty
focusing or concentrating; caused by triple repeat expansion
◉ What is Chediak-Higashi syndrome?
, Answer: phagocyte deficiency -> hypergammaglobulinemia,
significant neutropenia,
◉ In exposure to carbon monoxide or cyanide, which way does the
ox sat curve shift?
Answer: to the L; increased affinity at low pO_2
◉ What is pralidoxime chloride?
Answer: reactivate acetylcholinesterase
◉ Wernicke encephalopathy
Answer: inadequate thiamine; confusion, ophthalmoplagia
(nystagmus)
◉ What is the function of lactase?
Answer: beta(1->4) galactosidase; cleaves Gal from Glu
◉ How is fructose absorbed?
Answer: via sodium-independent transporter
◉ What sugar enzymes are found on the intestinal brush border?
Answer: sucrase, lactase, maltase, isomaltase
