CPJE CLINICAL COMPREHENSIVE TEST
BANK SOLVED QUESTIONS VERIFIED
ANSWERS RESOURCE
●● Ofirmev (IV) (I,D,Overdose)
Answer: Acetaminophen
I: fever/pain
D: < 4000mg/day from all sources
*Can treat more severe pain
*OD = liver damage, use NAC for antidote
no anti platelet activity
●● NAC (I)
Answer: N-acetylcysteine
I: APAP overdose
Compatible with: D5W, ½ NS, and Water for Injection
Stable for 24h at room temp
●● COX-1 selective NSAIDs
Answer: indomethacin, ketorlac
,COX-1 selective = higher risk for GI bleeding
●● COX-2 selective NSAIDs
Answer: Celecoxib
Diclofenac
Meloxicam
Etodolac
Nabumetone
COX-2 selective = higher risk of CV events (MI, stroke)
●● COX 1 and COX 2 non-selective NSAIDs
Answer: ibuprofen, naproxen, piroxicam, sulindac
COX-1 = higher risk for GI bleeding
COX-2 = higher risk of CV events (MI, stroke)
●● Daypro (I,D, BBW)
Answer: Oxaprozin
I: fever/pain/inflammation
*Similar caution to piroxicam: high risk for GI tox and severe SJS
Dose: 1200 mg once daily w/ max of 1800 mg if >50 kg
,BBW: COX non-selective: GI bleeding and CV thrombotic event risk
SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic +
ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib)
**FDA safety alert: Caution with use in pregnancy after 20 weeks, can
cause fetal renal tox / oligohydroaminos, avoid use after 30 weeks due to
risk of premature closure of fetal ductus arteriosus
CI: for use in patients w/ CABG surgery
requires med guide to be dispensed
●● Ascriptin, Bufferin, Ecotrin (I,D,CI,OD,BBW)
Answer: Aspirin (Bayer)
I: fever/pain/inflammation
D: 81-325mg qd
CI: pregnancy (esp 3rd trimester), OD = tinnitis
*BBW: COX-1 selectivity NSAID = GI bleed
Avoid in children < 16 with any vial infection due to potential risk of
Reye's syndrome
irreversible antiplatelet, GI toxicity
●● Naprosyn (I,D,BBW)
Answer: Naproxen, Aleve
I: fever/pain/inflammation
, -OTC: 220mg qd
-Rx: 250-550mg bid
*Higher GI side effects
*BBW: COX-1/2 selectivity NSAID = GI bleed and CV tox
SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic +
ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib)
CI: for use in patients w/ CABG surgery
requires med guide to be dispensed
●● Motrin, Advil (I,D,BBW, SE, CI)
Answer: Ibuprofen
I: fever/pain/inflammation
Dose
-OTC: 200-400mg q 4-6 hrs
-Rx: 600-800 mg tid, max 3200mg/d
child: 10mg/kg/dose with max 40mg/kg/day
COX non-selective: GI bleeding and CV thrombotic event risk
SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic +
ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib)
**FDA safety alert: Caution with use in pregnancy after 20 weeks, can
cause fetal renal tox / oligohydroaminos, avoid use after 30 weeks due to
risk of premature closure of fetal ductus arteriosus
CI: for use in patients w/ CABG surgery
BANK SOLVED QUESTIONS VERIFIED
ANSWERS RESOURCE
●● Ofirmev (IV) (I,D,Overdose)
Answer: Acetaminophen
I: fever/pain
D: < 4000mg/day from all sources
*Can treat more severe pain
*OD = liver damage, use NAC for antidote
no anti platelet activity
●● NAC (I)
Answer: N-acetylcysteine
I: APAP overdose
Compatible with: D5W, ½ NS, and Water for Injection
Stable for 24h at room temp
●● COX-1 selective NSAIDs
Answer: indomethacin, ketorlac
,COX-1 selective = higher risk for GI bleeding
●● COX-2 selective NSAIDs
Answer: Celecoxib
Diclofenac
Meloxicam
Etodolac
Nabumetone
COX-2 selective = higher risk of CV events (MI, stroke)
●● COX 1 and COX 2 non-selective NSAIDs
Answer: ibuprofen, naproxen, piroxicam, sulindac
COX-1 = higher risk for GI bleeding
COX-2 = higher risk of CV events (MI, stroke)
●● Daypro (I,D, BBW)
Answer: Oxaprozin
I: fever/pain/inflammation
*Similar caution to piroxicam: high risk for GI tox and severe SJS
Dose: 1200 mg once daily w/ max of 1800 mg if >50 kg
,BBW: COX non-selective: GI bleeding and CV thrombotic event risk
SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic +
ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib)
**FDA safety alert: Caution with use in pregnancy after 20 weeks, can
cause fetal renal tox / oligohydroaminos, avoid use after 30 weeks due to
risk of premature closure of fetal ductus arteriosus
CI: for use in patients w/ CABG surgery
requires med guide to be dispensed
●● Ascriptin, Bufferin, Ecotrin (I,D,CI,OD,BBW)
Answer: Aspirin (Bayer)
I: fever/pain/inflammation
D: 81-325mg qd
CI: pregnancy (esp 3rd trimester), OD = tinnitis
*BBW: COX-1 selectivity NSAID = GI bleed
Avoid in children < 16 with any vial infection due to potential risk of
Reye's syndrome
irreversible antiplatelet, GI toxicity
●● Naprosyn (I,D,BBW)
Answer: Naproxen, Aleve
I: fever/pain/inflammation
, -OTC: 220mg qd
-Rx: 250-550mg bid
*Higher GI side effects
*BBW: COX-1/2 selectivity NSAID = GI bleed and CV tox
SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic +
ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib)
CI: for use in patients w/ CABG surgery
requires med guide to be dispensed
●● Motrin, Advil (I,D,BBW, SE, CI)
Answer: Ibuprofen
I: fever/pain/inflammation
Dose
-OTC: 200-400mg q 4-6 hrs
-Rx: 600-800 mg tid, max 3200mg/d
child: 10mg/kg/dose with max 40mg/kg/day
COX non-selective: GI bleeding and CV thrombotic event risk
SE: anemia, skin rash, asthma exacerbation, renal (NSAID + diuretic +
ACE/ARB) / hepatic tox (least risk with ibuprofen / celecoxib)
**FDA safety alert: Caution with use in pregnancy after 20 weeks, can
cause fetal renal tox / oligohydroaminos, avoid use after 30 weeks due to
risk of premature closure of fetal ductus arteriosus
CI: for use in patients w/ CABG surgery
