, Test Bank V!
to accompany
V!
Psychopharmacology, Fourth Edition V! V!
Meyer • Quenzer V! V!
Chapter 1: Principles of Pharmacology V! V! V! V!
Multiple Choice V!
1. refer(s) to specific molecular changes that occur when a drug binds to a
V! V! V! V! V! V! V! V! V! V! V! V! V!
particular target site or receptor, while
V! V! V! V! V!
are the resulting widespread alterations in function.
V! V! V! V! V! V!
a. Drug action; therapeutic effects
V! V! V!
b. Side effects; drug effects
V! V! V!
c. Therapeutic effects; side effects V! V! V!
d. Drug action; drug effects
V! V! V!
Answer: d V!
Textbook Reference: Pharmacology: The Science of Drug Action
V! V! V! V! V! V! V!
2. After drug administration has occurred, the amount of drug in the blood that is free
V! V! V! V! V! V! V! V! V! V! V! V! V! V!
to bind at specific target sites is referred to as
V! V! V! V! V! V! V! V! V! V!
a. the therapeutic dose.
V! V!
b. first-pass effects. V!
c. bioavailability.
d. ED50.
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
3. The specific molecular changes that occur when a drug binds to a particular target s
V! V! V! V! V! V! V! V! V! V! V! V! V! V!
ite or receptor are referred to as
V! V! V! V! V! V!
a. drug effects.V!
b. drug action. V!
c. side effects.
V!
d. placebo effects. V!
Answer: b V!
Textbook Reference: Pharmacology: The Science of Drug Action
V! V! V! V! V! V! V!
4. Which of the following is not a possible explanation for placebo effects?
V! V! V! V! V! V! V! V! V! V! V!
a. Pavlovian conditioning V!
b. Genetic variation V!
c. Drug competition V!
d. Expectation of outcome V! V!
Answer: c V!
Textbook Reference: Pharmacology: The Science of Drug Action
V! V! V! V! V! V! V!
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V! V! V!
,5. The administration of oxytocin has been proposed as a treatment for autism. V! V! V! V! V! V! V! V! V! V!
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
6. Which factor does not affect the pharmacokinetics of a drug?
V! V! V! V! V! V! V! V! V!
a. Route of administration
V! V!
b. Lipid solubility
V!
c. Depot binding V!
d. Drug action V!
Answer: d V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
7. First-pass metabolism occurs when drugs are taken
V! V! V! V! V! V!
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
8. The area postrema is one area in the brain where the
V! V! is not complete.
V! V! V! V! V! V! V! V! V! V!
a. cerebrospinal fluid V!
b. blood–brain barrier V!
c. choroid plexus V!
d. phospholipid membrane V!
Answer: b V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
9. First-pass metabolism occurs with orally administered drugs because
V! V! V! V! V! V! V!
a. their absorption is slowed by food.
V! V! V! V! V!
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wa
V! V! V! V! V! V! V! V! V! V! V! V! V! V!
y to general circulation.
V! V! V!
c. drugs must first survive the acidic environment of the stomach.
V! V! V! V! V! V! V! V! V!
d. salivary enzymes in the mouth begin the process of metabolism.
V! V! V! V! V! V! V! V! V!
Answer: b V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
10. Toxic substances in the blood trigger a vomiting response by activating the
V! V! V! V! V! V! V! V! V! V! V!
a. blood–brain barrier. V!
b. choroid plexus. V!
c. area postrema.
V!
d. median eminence. V!
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V! V! V!
, Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
11. Drugs administered _ V! have the most rapid onset of action. V! V! V! V! V! V! V!
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
12. Ionization of a drug depends on the
V! of the solution and the
V! V! V! V! V! V! V! V! V!
of the drug.
V! V!
a. pH; pKa
V!
b. pKa; pH V!
c. concentration; lipid solubility V! V!
d. pH; concentration
V!
Answer: a V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
13. The absorption of a drug depends on all of the following except
V! V! V! V! V! V! V! V! V! V! V!
a. lipid solubility.
V!
b. ionization.
c. body temperature.
V!
d. the concentration of the drug.
V! V! V! V!
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
14. Drugs that are V!should be avoided by women of childbearing age.
V! V! V! V! V! V! V! V!
a. teratogenic
b. able to cross the placental barrier
V! V! V! V! V!
c. psychoactive
d. highly lipid-soluble
V!
Answer: a V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
15. Agents that induce developmental abnormalities in a fetus are known as
V! V! V! V! V! V! V! V! V! V!
a. psychoactive drugs. V!
b. illicit drugs.
V!
c. teratogens.
d. placental drugs. V!
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
16. Depot binding is said to occur when drugs
V! V! V! V! V! V! V!
a. bind to their target sites.
V! V! V! V!
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V! V! V!
to accompany
V!
Psychopharmacology, Fourth Edition V! V!
Meyer • Quenzer V! V!
Chapter 1: Principles of Pharmacology V! V! V! V!
Multiple Choice V!
1. refer(s) to specific molecular changes that occur when a drug binds to a
V! V! V! V! V! V! V! V! V! V! V! V! V!
particular target site or receptor, while
V! V! V! V! V!
are the resulting widespread alterations in function.
V! V! V! V! V! V!
a. Drug action; therapeutic effects
V! V! V!
b. Side effects; drug effects
V! V! V!
c. Therapeutic effects; side effects V! V! V!
d. Drug action; drug effects
V! V! V!
Answer: d V!
Textbook Reference: Pharmacology: The Science of Drug Action
V! V! V! V! V! V! V!
2. After drug administration has occurred, the amount of drug in the blood that is free
V! V! V! V! V! V! V! V! V! V! V! V! V! V!
to bind at specific target sites is referred to as
V! V! V! V! V! V! V! V! V! V!
a. the therapeutic dose.
V! V!
b. first-pass effects. V!
c. bioavailability.
d. ED50.
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
3. The specific molecular changes that occur when a drug binds to a particular target s
V! V! V! V! V! V! V! V! V! V! V! V! V! V!
ite or receptor are referred to as
V! V! V! V! V! V!
a. drug effects.V!
b. drug action. V!
c. side effects.
V!
d. placebo effects. V!
Answer: b V!
Textbook Reference: Pharmacology: The Science of Drug Action
V! V! V! V! V! V! V!
4. Which of the following is not a possible explanation for placebo effects?
V! V! V! V! V! V! V! V! V! V! V!
a. Pavlovian conditioning V!
b. Genetic variation V!
c. Drug competition V!
d. Expectation of outcome V! V!
Answer: c V!
Textbook Reference: Pharmacology: The Science of Drug Action
V! V! V! V! V! V! V!
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Page 1 of 247
V! V! V!
,5. The administration of oxytocin has been proposed as a treatment for autism. V! V! V! V! V! V! V! V! V! V!
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
6. Which factor does not affect the pharmacokinetics of a drug?
V! V! V! V! V! V! V! V! V!
a. Route of administration
V! V!
b. Lipid solubility
V!
c. Depot binding V!
d. Drug action V!
Answer: d V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
7. First-pass metabolism occurs when drugs are taken
V! V! V! V! V! V!
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
8. The area postrema is one area in the brain where the
V! V! is not complete.
V! V! V! V! V! V! V! V! V! V!
a. cerebrospinal fluid V!
b. blood–brain barrier V!
c. choroid plexus V!
d. phospholipid membrane V!
Answer: b V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
9. First-pass metabolism occurs with orally administered drugs because
V! V! V! V! V! V! V!
a. their absorption is slowed by food.
V! V! V! V! V!
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wa
V! V! V! V! V! V! V! V! V! V! V! V! V! V!
y to general circulation.
V! V! V!
c. drugs must first survive the acidic environment of the stomach.
V! V! V! V! V! V! V! V! V!
d. salivary enzymes in the mouth begin the process of metabolism.
V! V! V! V! V! V! V! V! V!
Answer: b V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
10. Toxic substances in the blood trigger a vomiting response by activating the
V! V! V! V! V! V! V! V! V! V! V!
a. blood–brain barrier. V!
b. choroid plexus. V!
c. area postrema.
V!
d. median eminence. V!
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V! V! V!
, Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
11. Drugs administered _ V! have the most rapid onset of action. V! V! V! V! V! V! V!
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
12. Ionization of a drug depends on the
V! of the solution and the
V! V! V! V! V! V! V! V! V!
of the drug.
V! V!
a. pH; pKa
V!
b. pKa; pH V!
c. concentration; lipid solubility V! V!
d. pH; concentration
V!
Answer: a V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
13. The absorption of a drug depends on all of the following except
V! V! V! V! V! V! V! V! V! V! V!
a. lipid solubility.
V!
b. ionization.
c. body temperature.
V!
d. the concentration of the drug.
V! V! V! V!
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
14. Drugs that are V!should be avoided by women of childbearing age.
V! V! V! V! V! V! V! V!
a. teratogenic
b. able to cross the placental barrier
V! V! V! V! V!
c. psychoactive
d. highly lipid-soluble
V!
Answer: a V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
15. Agents that induce developmental abnormalities in a fetus are known as
V! V! V! V! V! V! V! V! V! V!
a. psychoactive drugs. V!
b. illicit drugs.
V!
c. teratogens.
d. placental drugs. V!
Answer: c V!
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
V! V! V! V! V! V!
16. Depot binding is said to occur when drugs
V! V! V! V! V! V! V!
a. bind to their target sites.
V! V! V! V!
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V! V! V!
