Exam
2026/2027
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, Mitochondrial proteins are completely [......] synthesized into the cytoplasm first
mitochondrial proteins are completely synthesized in imported into the mitochondria
the cytoplasm first, then [......]
Protein Import into the Mitochondria: Step 1 protein is fully translated in the cytoplasm
Protein Import into the Mitochondria: Step 2 protein contains a presequence
pre sequence positively charged mitochondrial signal sequence
Protein Import into the Mitochondria: Step 3 Cytoplasmuc Hsp70 chaperone unfolds the protein
Protein Import into the Mitochondria: Step 4 Presequence binds TOM receptor
Protein Import into the Mitochondria: Step 5 Protein passes through TOM pore
Protein Import into the Mitochondria: Step 6 Protein binds TIM receptor (Inner mitochondrial membrane)
Protein Import into the Mitochondria: Step 7 PAM + mtHsp70 pull protein into the mitochondrial matrix
Protein Import into the Mitochondria: Step 8 Mitochondrial processing peptidase removes the signal sequence
Protein Import into the Mitochondria: Step 9 Chaperones refold the protein
protein: Hsp70 unfolds protein
protein: TOM outer membrane receptor/channel
protein: TIM inner membrane receptor/channel
protein: PAM motor that pulls protein inside
protein: mtHsp70 assists import