Stuvia.com - The Marketplace to Buy and Sell your Study Material
MOLECULAR BIOLOGY OF THE CELL, SIXTH EDITION BRUCE
ALBERTS TEST BANK
ANSWERS ARE BELOW
CHAPTER 4: DNA, CHROMOSOMES, AND GENOMES
1 In A Double-Stranded DNA Molecule, One Of The Chains Has The Sequence
CCCATTCTA When Read From The 5′ To The 3′ End. Indicate True (T) And False (F)
Statements Below Regarding This Chain. Your Answer Would Be A Four-Letter String
Composed Of Letters T And F Only, E.G. TTFT.
( T ) The Other Chain Is Heavier, I.E. It Has A Greater
Mass. ( T) There Are No C Residues In The Other
Chain.
( F) The 5′-Terminal Residue Of The Other
Chain Is G. ( F ) The Other Chain Is
Pyrimidine-Rich.
2 Indicate Which Numbered Feature (1 To 5) In The Schematic Drawing Below Of The
DNA Double Helix Corresponds To Each Of The Following. Your Answer Would Be A Five-
Digit Number Composed Of Digits 1 To 5 Only, E.G. 52431.
1
3
2
4
5
( 4) Hydrogen-Bonding
( 3 ) Covalent
Linkage ( 2 )
Phosphate Group
( 1 ) Nitrogen-Containing
Base ( 5 ) Deoxyribose
, Stuvia.com - The Marketplace to Buy and Sell your Study Material
Sugar
3 Complete The DNA Sequence Below Such That The Final Sequence Is Identical To
That Of The Complementary Strand. Your Answer Would Be A Seven-Letter String
Composed Of Letters A, C, T, And G Only, E.G. TTCTCAG.
5′- C T T T A G A T C T A A A G -3′
4 A DNA Nucleotide Pair Has An Average Mass Of Approximately 660 Daltons.
Knowing The Number Of Nucleotides In The Human Genome, How Many Picograms Of DNA
Are There In A Diploid Human Nucleus? Avogadro’s Number Is 6 × 1023. Write Down The
Picogram Amount Without Decimals (Round The Number To The Closest Integer), E.G. 23
Pg.
5 Which Of The Following Features Of DNA Underlies Its Simple Replication Procedure?
A. The Fact That It Is Composed Of Only Four Different Types Of Bases
B. The Antiparallel Arrangement Of The Double Helix
C. The Complementary Relationship In The Double Helix
D. The Fact That There Is A Major Groove And A Minor Groove In The Double Helix
6 Which Of The Following Correlates The Best With Biological Complexity In Eukaryotes?
A. Number Of Genes Per Chromosome
B. Number Of Chromosomes
C. Number Of Genes
D. Genome Size (Number Of Nucleotide Pairs)
7 Indicate True (T) And False (F) Statements Below About The Human Genome. Your
Answer Would Be A Six-Letter String Composed Of Letters T And F Only, E.G. FTFFFT.
( F) Only About 1.5% Of The Human Genome Is Highly Conserved.
( T) Almost Half Of Our Genome Is Composed Of Repetitive
Sequences. ( T ) Genes Occupy Almost A Quarter Of The
Genome.
( T) There Are Roughly As Many Pseudogenes In The Human Genome As
Functional Genes.
( F) Transposable Elements Occupy Almost 10% Of Our
Genome. ( F) On Average, Exons Comprise 1.5% Of Our
Genes.
, Stuvia.com - The Marketplace to Buy and Sell your Study Material
8 Chromosome 3 Contains Nearly 200 Million Nucleotide Pairs Of Our Genome. If This
DNA Molecule Could Be Laid End To End, How Long Would It Be? The Distance Between
Neighboring Base Pairs In DNA Is Typically Around 0.34 Nm.
A. About 7 Mm
B. About 7 Cm
C. About 70 Cm
D. About 7 M
E. None Of The Above
9 For The Human Genome Project, Cloning Of Large Segments Of Our Genome Was
First Made Possible By The Development Of Yeast Artificial Chromosomes, Which Are
Capable Of Propagating In The Yeast Saccharomyces Cerevisiae Just Like Any Of The
Organism’s 16 Natural Chromosomes. In Addition To The Cloned Human DNA, These
Artificial Vectors Were Made To Contain Three Elements That Are Necessary For Them To
Function As A Chromosome. What Are These Elements? Write Down The Names Of The
Elements In Alphabetical Order, And Separate Them With Commas,
E.G. Gene, Histone, Nucleosome.
CENTROMERE, ORIGIN OF REPLICATION, TELOMERE
10 Indicate Whether Each Of The Following Descriptions Better Applies To A
Centromere (C), A Telomere (T), Or An Origin Of Replication (O). Your Answer Would Be A
Seven-Letter String Composed Of Letters C, T, And O Only, E.G. TTTCCTO.
( T ) It Contains Repeated Sequences At The Ends Of The Chromosomes.
( T) It Is NOT Generally Longer In Higher Organisms Compared To
Yeast. ( O ) Each Eukaryotic Chromosome Has Many Such Sequences.
( T) There Are Normally Two Such Sequences In Each Eukaryotic Chromosomal
DNA Molecule.
( C ) There Is Normally One Such Sequence Per Eukaryotic Chromosomal
DNA Molecule.
( O) It Is Where DNA Duplication Starts In S Phase.
( C ) It Attaches The Chromosome To The Mitotic Spindle Via The Kinetochore
Structure.
11 The Eukaryotic Chromosomes Are Organized Inside The Nucleus With A Huge
Compaction Ratio Of Several-Thousand-Fold. What Is Responsible For Such A Tight
Packaging?
A. The Various Chromatin Proteins That Wrap And Fold The DNA
B. The Nuclear Envelope Which Encapsulates The Chromosomes
C. The Nuclear Matrix That Provides A Firm Scaffold
D. All Of The Above
, Stuvia.com - The Marketplace to Buy and Sell your Study Material
12 The Two Chromosomes In Each Of The 22 Homologous Pairs In Our Cells ...
A. Have The Exact Same DNA Sequence.
B. Are Derived From One Of Our Parents.
C. Show Identical Banding Patterns After Giemsa Staining.
D. Usually Bear Different Sets Of Genes.
E. All Of The Above.
13 Compared To The Human Genome, The Genome Of Yeast Typically Has …
A. More Repetitive DNA.
B. Longer Genes.
C. More Introns.
D. Longer Chromosomes.
E. A Higher Fraction Of Coding DNA.
14 Indicate True (T) And False (F) Statements Below Regarding Histones. Your Answer
Would Be A Six-Letter String Composed Of Letters T And F Only, E.G. TTFFFF.
( F) The Histones Are Highly Acidic Proteins.
(T) The Histone Fold Consists Of Three Α Helices.
(T) The Core Histones Are Much More Conserved Than The H1 Histone.
(T) The N-Terminal Tails Of The Core Histones Undergo A Variety Of
Reversible Post-Translational Modifications.
( F) Every Nucleosome Core Is Made Up Of Three Polypeptide
Chains. ( F) The H1 Histone Is Absent In The 30-Nm Fibers.
15 Indicate Which Feature (1 To 4) In The Schematic Drawing Below Of A Chromatin
Fiber Corresponds To Each Of The Following. Your Answer Would Be A Four-Digit Number
Composed Of Digits 1 To 4 Only, E.G. 2431.
MOLECULAR BIOLOGY OF THE CELL, SIXTH EDITION BRUCE
ALBERTS TEST BANK
ANSWERS ARE BELOW
CHAPTER 4: DNA, CHROMOSOMES, AND GENOMES
1 In A Double-Stranded DNA Molecule, One Of The Chains Has The Sequence
CCCATTCTA When Read From The 5′ To The 3′ End. Indicate True (T) And False (F)
Statements Below Regarding This Chain. Your Answer Would Be A Four-Letter String
Composed Of Letters T And F Only, E.G. TTFT.
( T ) The Other Chain Is Heavier, I.E. It Has A Greater
Mass. ( T) There Are No C Residues In The Other
Chain.
( F) The 5′-Terminal Residue Of The Other
Chain Is G. ( F ) The Other Chain Is
Pyrimidine-Rich.
2 Indicate Which Numbered Feature (1 To 5) In The Schematic Drawing Below Of The
DNA Double Helix Corresponds To Each Of The Following. Your Answer Would Be A Five-
Digit Number Composed Of Digits 1 To 5 Only, E.G. 52431.
1
3
2
4
5
( 4) Hydrogen-Bonding
( 3 ) Covalent
Linkage ( 2 )
Phosphate Group
( 1 ) Nitrogen-Containing
Base ( 5 ) Deoxyribose
, Stuvia.com - The Marketplace to Buy and Sell your Study Material
Sugar
3 Complete The DNA Sequence Below Such That The Final Sequence Is Identical To
That Of The Complementary Strand. Your Answer Would Be A Seven-Letter String
Composed Of Letters A, C, T, And G Only, E.G. TTCTCAG.
5′- C T T T A G A T C T A A A G -3′
4 A DNA Nucleotide Pair Has An Average Mass Of Approximately 660 Daltons.
Knowing The Number Of Nucleotides In The Human Genome, How Many Picograms Of DNA
Are There In A Diploid Human Nucleus? Avogadro’s Number Is 6 × 1023. Write Down The
Picogram Amount Without Decimals (Round The Number To The Closest Integer), E.G. 23
Pg.
5 Which Of The Following Features Of DNA Underlies Its Simple Replication Procedure?
A. The Fact That It Is Composed Of Only Four Different Types Of Bases
B. The Antiparallel Arrangement Of The Double Helix
C. The Complementary Relationship In The Double Helix
D. The Fact That There Is A Major Groove And A Minor Groove In The Double Helix
6 Which Of The Following Correlates The Best With Biological Complexity In Eukaryotes?
A. Number Of Genes Per Chromosome
B. Number Of Chromosomes
C. Number Of Genes
D. Genome Size (Number Of Nucleotide Pairs)
7 Indicate True (T) And False (F) Statements Below About The Human Genome. Your
Answer Would Be A Six-Letter String Composed Of Letters T And F Only, E.G. FTFFFT.
( F) Only About 1.5% Of The Human Genome Is Highly Conserved.
( T) Almost Half Of Our Genome Is Composed Of Repetitive
Sequences. ( T ) Genes Occupy Almost A Quarter Of The
Genome.
( T) There Are Roughly As Many Pseudogenes In The Human Genome As
Functional Genes.
( F) Transposable Elements Occupy Almost 10% Of Our
Genome. ( F) On Average, Exons Comprise 1.5% Of Our
Genes.
, Stuvia.com - The Marketplace to Buy and Sell your Study Material
8 Chromosome 3 Contains Nearly 200 Million Nucleotide Pairs Of Our Genome. If This
DNA Molecule Could Be Laid End To End, How Long Would It Be? The Distance Between
Neighboring Base Pairs In DNA Is Typically Around 0.34 Nm.
A. About 7 Mm
B. About 7 Cm
C. About 70 Cm
D. About 7 M
E. None Of The Above
9 For The Human Genome Project, Cloning Of Large Segments Of Our Genome Was
First Made Possible By The Development Of Yeast Artificial Chromosomes, Which Are
Capable Of Propagating In The Yeast Saccharomyces Cerevisiae Just Like Any Of The
Organism’s 16 Natural Chromosomes. In Addition To The Cloned Human DNA, These
Artificial Vectors Were Made To Contain Three Elements That Are Necessary For Them To
Function As A Chromosome. What Are These Elements? Write Down The Names Of The
Elements In Alphabetical Order, And Separate Them With Commas,
E.G. Gene, Histone, Nucleosome.
CENTROMERE, ORIGIN OF REPLICATION, TELOMERE
10 Indicate Whether Each Of The Following Descriptions Better Applies To A
Centromere (C), A Telomere (T), Or An Origin Of Replication (O). Your Answer Would Be A
Seven-Letter String Composed Of Letters C, T, And O Only, E.G. TTTCCTO.
( T ) It Contains Repeated Sequences At The Ends Of The Chromosomes.
( T) It Is NOT Generally Longer In Higher Organisms Compared To
Yeast. ( O ) Each Eukaryotic Chromosome Has Many Such Sequences.
( T) There Are Normally Two Such Sequences In Each Eukaryotic Chromosomal
DNA Molecule.
( C ) There Is Normally One Such Sequence Per Eukaryotic Chromosomal
DNA Molecule.
( O) It Is Where DNA Duplication Starts In S Phase.
( C ) It Attaches The Chromosome To The Mitotic Spindle Via The Kinetochore
Structure.
11 The Eukaryotic Chromosomes Are Organized Inside The Nucleus With A Huge
Compaction Ratio Of Several-Thousand-Fold. What Is Responsible For Such A Tight
Packaging?
A. The Various Chromatin Proteins That Wrap And Fold The DNA
B. The Nuclear Envelope Which Encapsulates The Chromosomes
C. The Nuclear Matrix That Provides A Firm Scaffold
D. All Of The Above
, Stuvia.com - The Marketplace to Buy and Sell your Study Material
12 The Two Chromosomes In Each Of The 22 Homologous Pairs In Our Cells ...
A. Have The Exact Same DNA Sequence.
B. Are Derived From One Of Our Parents.
C. Show Identical Banding Patterns After Giemsa Staining.
D. Usually Bear Different Sets Of Genes.
E. All Of The Above.
13 Compared To The Human Genome, The Genome Of Yeast Typically Has …
A. More Repetitive DNA.
B. Longer Genes.
C. More Introns.
D. Longer Chromosomes.
E. A Higher Fraction Of Coding DNA.
14 Indicate True (T) And False (F) Statements Below Regarding Histones. Your Answer
Would Be A Six-Letter String Composed Of Letters T And F Only, E.G. TTFFFF.
( F) The Histones Are Highly Acidic Proteins.
(T) The Histone Fold Consists Of Three Α Helices.
(T) The Core Histones Are Much More Conserved Than The H1 Histone.
(T) The N-Terminal Tails Of The Core Histones Undergo A Variety Of
Reversible Post-Translational Modifications.
( F) Every Nucleosome Core Is Made Up Of Three Polypeptide
Chains. ( F) The H1 Histone Is Absent In The 30-Nm Fibers.
15 Indicate Which Feature (1 To 4) In The Schematic Drawing Below Of A Chromatin
Fiber Corresponds To Each Of The Following. Your Answer Would Be A Four-Digit Number
Composed Of Digits 1 To 4 Only, E.G. 2431.
