1|Page
NCLEX-RN Safety & Infection Control
Expanded Questions And Well Graded
Solutions With Rationales Updated
2026-2027
A nurse is caring for a client with active tuberculosis. Which type of precautions should
the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: D
Rationale: Tuberculosis is transmitted via airborne droplet nuclei and requires
airborne precautions (D). Standard (A), contact (B), and droplet (C) precautions
are not sufficient. The client should be placed in a negative pressure room.
2. A nurse is caring for a client with Clostridium difficile infection. Which type of
precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: B
Rationale: C. difficile is transmitted via spores on contaminated surfaces and
requires contact precautions (B). Alcohol-based hand sanitizer is not effective
against C. difficile spores; hand washing with soap and water is required.
3. A nurse is caring for a client with influenza. Which type of precautions should the
nurse implement?
A) Standard precautions
B) Contact precautions
, 2|Page
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Influenza is transmitted via respiratory droplets and requires droplet
precautions (C). A surgical mask should be worn when entering the room.
Standard (A), contact (B), and airborne (D) precautions are not sufficient.
4. A nurse is caring for a client with measles. Which type of precautions should the
nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: D
Rationale: Measles is highly contagious and transmitted via airborne droplets,
requiring airborne precautions (D). An N95 respirator is required. Standard (A),
contact (B), and droplet (C) precautions are not sufficient.
5. A nurse is caring for a client with varicella (chickenpox). Which type of precautions
should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: D
Rationale: Varicella is transmitted via airborne droplets and requires airborne
precautions (D). An N95 respirator is required. Standard (A), contact (B), and
droplet (C) precautions are not sufficient.
6. A nurse is caring for a client with pertussis. Which type of precautions should the
nurse implement?
, 3|Page
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Pertussis (whooping cough) is transmitted via respiratory droplets
and requires droplet precautions (C). A surgical mask should be worn when
entering the room. Standard (A), contact (B), and airborne (D) precautions are
not sufficient.
7. A nurse is caring for a client with meningococcal meningitis. Which type of
precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Meningococcal meningitis is transmitted via respiratory droplets and
requires droplet precautions (C). A surgical mask should be worn when entering
the room. Standard (A), contact (B), and airborne (D) precautions are not
sufficient.
8. A nurse is caring for a client with rubella. Which type of precautions should the nurse
implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Rubella (German measles) is transmitted via respiratory droplets and
requires droplet precautions (C). Standard (A), contact (B), and airborne (D)
precautions are not sufficient.
, 4|Page
9. A nurse is caring for a client with mumps. Which type of precautions should the
nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Mumps is transmitted via respiratory droplets and requires droplet
precautions (C). Standard (A), contact (B), and airborne (D) precautions are not
sufficient.
10. A nurse is caring for a client with methicillin-resistant Staphylococcus aureus (MRSA)
wound infection. Which type of precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: B
Rationale: MRSA is transmitted via direct contact with contaminated surfaces or
skin and requires contact precautions (B). Gown and gloves are required.
Standard (A), droplet (C), and airborne (D) precautions are not sufficient.
11. A nurse is caring for a client with vancomycin-resistant Enterococcus (VRE). Which
type of precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: B
Rationale: VRE is transmitted via direct contact and requires contact
NCLEX-RN Safety & Infection Control
Expanded Questions And Well Graded
Solutions With Rationales Updated
2026-2027
A nurse is caring for a client with active tuberculosis. Which type of precautions should
the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: D
Rationale: Tuberculosis is transmitted via airborne droplet nuclei and requires
airborne precautions (D). Standard (A), contact (B), and droplet (C) precautions
are not sufficient. The client should be placed in a negative pressure room.
2. A nurse is caring for a client with Clostridium difficile infection. Which type of
precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: B
Rationale: C. difficile is transmitted via spores on contaminated surfaces and
requires contact precautions (B). Alcohol-based hand sanitizer is not effective
against C. difficile spores; hand washing with soap and water is required.
3. A nurse is caring for a client with influenza. Which type of precautions should the
nurse implement?
A) Standard precautions
B) Contact precautions
, 2|Page
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Influenza is transmitted via respiratory droplets and requires droplet
precautions (C). A surgical mask should be worn when entering the room.
Standard (A), contact (B), and airborne (D) precautions are not sufficient.
4. A nurse is caring for a client with measles. Which type of precautions should the
nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: D
Rationale: Measles is highly contagious and transmitted via airborne droplets,
requiring airborne precautions (D). An N95 respirator is required. Standard (A),
contact (B), and droplet (C) precautions are not sufficient.
5. A nurse is caring for a client with varicella (chickenpox). Which type of precautions
should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: D
Rationale: Varicella is transmitted via airborne droplets and requires airborne
precautions (D). An N95 respirator is required. Standard (A), contact (B), and
droplet (C) precautions are not sufficient.
6. A nurse is caring for a client with pertussis. Which type of precautions should the
nurse implement?
, 3|Page
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Pertussis (whooping cough) is transmitted via respiratory droplets
and requires droplet precautions (C). A surgical mask should be worn when
entering the room. Standard (A), contact (B), and airborne (D) precautions are
not sufficient.
7. A nurse is caring for a client with meningococcal meningitis. Which type of
precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Meningococcal meningitis is transmitted via respiratory droplets and
requires droplet precautions (C). A surgical mask should be worn when entering
the room. Standard (A), contact (B), and airborne (D) precautions are not
sufficient.
8. A nurse is caring for a client with rubella. Which type of precautions should the nurse
implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Rubella (German measles) is transmitted via respiratory droplets and
requires droplet precautions (C). Standard (A), contact (B), and airborne (D)
precautions are not sufficient.
, 4|Page
9. A nurse is caring for a client with mumps. Which type of precautions should the
nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: C
Rationale: Mumps is transmitted via respiratory droplets and requires droplet
precautions (C). Standard (A), contact (B), and airborne (D) precautions are not
sufficient.
10. A nurse is caring for a client with methicillin-resistant Staphylococcus aureus (MRSA)
wound infection. Which type of precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: B
Rationale: MRSA is transmitted via direct contact with contaminated surfaces or
skin and requires contact precautions (B). Gown and gloves are required.
Standard (A), droplet (C), and airborne (D) precautions are not sufficient.
11. A nurse is caring for a client with vancomycin-resistant Enterococcus (VRE). Which
type of precautions should the nurse implement?
A) Standard precautions
B) Contact precautions
C) Droplet precautions
D) Airborne precautions
Correct Answer: B
Rationale: VRE is transmitted via direct contact and requires contact
